Cited 0 times in

51 5

Electroanatomic remodeling of the left stellate ganglion after myocardial infarction.

Authors
 Seongwook Han ; Kenzaburo Kobayashi ; Lan S. Chen ; Peng-Sheng Chen ; Michael C. Fishbein ; Changyu Shen ; Shien-Fong Lin ; Keith March ; Harry V. Vinters ; Mitsunori Maruyama ; Gianfranco Piccirillo ; Boyoung Joung 
Citation
 Journal of the American College of Cardiology, Vol.59(10) : 954~961, 2012 
Journal Title
 Journal of the American College of Cardiology 
ISSN
 0735-1097 
Issue Date
2012
Abstract
OBJECTIVES: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). BACKGROUND: Whether MI results in remodeling of extracardiac nerve activity remains unclear. METHODS: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. RESULTS: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm(2)/mm(2) and 20,623 ± 4,926 μm(2)/mm(2) for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm(2)/mm(2)and 16,326 ± 4,679 μm(2)/mm(2) for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). CONCLUSIONS: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91111
DOI
10.1016/j.jacc.2011.11.030
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0735109711052727
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse