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Early cardiac evaluation in children with non-specific mitochondrial disease with isolated mitochondrial respiratory chain complex I defect.
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이영목 | - |
dc.contributor.author | 이준수 | - |
dc.date.accessioned | 2014-12-19T17:14:07Z | - |
dc.date.available | 2014-12-19T17:14:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1034-4810 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91031 | - |
dc.description.abstract | AIMS: We evaluated echocardiography and electrocardiography (ECG) results in children with non-specific mitochondrial disease (MD) in order to study early cardiac involvement, a well-known complication of the disease. METHODS: Among non-specific MD children whose isolated mitochondrial respiratory chain complex I defect was confirmed by muscle biopsy and satisfied the criteria of MD, 27 who had no cardiac symptoms were evaluated by echocardiography and ECG. RESULTS: Three (11.1%) out of the 27 non-specific MD patients had left ventricular ejection fraction of less than 55% and two of them (7.4%) had fractional shortening of less than 26%. ECG abnormalities were observed in 16 of the non-specific MD patients (59.3%). Prolongation of heart rate-corrected QT interval was seen in 11 (40.7%) and widening of the QRS interval in eight (29.6%). Left ventricular ejection fraction and fractional shortening of the patients were significantly decreased compared with those in the control group while heart rate-corrected QT interval was prolonged in the former group. QRS interval was more widened in non-specific MD patients, but without statistical significance. CONCLUSION: The potentially severe cardiac involvement observed in our subjects suggests that early cardiac evaluation after confirming the diagnosis of MD and regular follow-up tests should be strongly recommended in children even in cases without typical cardiac manifestations. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF PAEDIATRICS AND CHILD HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Arrhythmias, Cardiac/diagnostic imaging | - |
dc.subject.MESH | Arrhythmias, Cardiac/etiology | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Early Diagnosis | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Electron Transport Complex I*/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mitochondrial Diseases/complications | - |
dc.subject.MESH | Mitochondrial Diseases/diagnostic imaging | - |
dc.subject.MESH | Mitochondrial Diseases/physiopathology* | - |
dc.subject.MESH | Myocardial Contraction/physiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Ventricular Dysfunction, Left/diagnostic imaging | - |
dc.subject.MESH | Ventricular Dysfunction, Left/etiology | - |
dc.title | Early cardiac evaluation in children with non-specific mitochondrial disease with isolated mitochondrial respiratory chain complex I defect. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Ran Baik | - |
dc.contributor.googleauthor | Rita Yu | - |
dc.contributor.googleauthor | Young Mock Lee | - |
dc.contributor.googleauthor | Hoon Chul Kang | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.identifier.doi | 23038991 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A02955 | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J01675 | - |
dc.identifier.eissn | 1440-1754 | - |
dc.identifier.pmid | 23038991 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2012.02585.x/abstract | - |
dc.subject.keyword | Arrhythmias, Cardiac/diagnostic imaging | - |
dc.subject.keyword | Arrhythmias, Cardiac/etiology | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Child, Preschool | - |
dc.subject.keyword | Early Diagnosis | - |
dc.subject.keyword | Echocardiography | - |
dc.subject.keyword | Electrocardiography | - |
dc.subject.keyword | Electron Transport Complex I*/metabolism | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Mitochondrial Diseases/complications | - |
dc.subject.keyword | Mitochondrial Diseases/diagnostic imaging | - |
dc.subject.keyword | Mitochondrial Diseases/physiopathology* | - |
dc.subject.keyword | Myocardial Contraction/physiology | - |
dc.subject.keyword | Retrospective Studies | - |
dc.subject.keyword | Ventricular Dysfunction, Left/diagnostic imaging | - |
dc.subject.keyword | Ventricular Dysfunction, Left/etiology | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.alternativeName | Lee, Young Mock | - |
dc.contributor.alternativeName | Lee, Joon Soo | - |
dc.contributor.affiliatedAuthor | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Lee, Young Mock | - |
dc.contributor.affiliatedAuthor | Lee, Joon Soo | - |
dc.citation.volume | 48 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1016 | - |
dc.citation.endPage | 1020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Vol.48(11) : 1016-1020, 2012 | - |
dc.identifier.rimsid | 33288 | - |
dc.type.rims | ART | - |
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