Cited 17 times in
Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2014-12-19T17:13:28Z | - |
dc.date.available | 2014-12-19T17:13:28Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1355-0284 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91010 | - |
dc.description.abstract | Since HIV-1 Tat has been associated with neurocognitive dysfunction, we investigated 60 HIV-1 subtype B-infected individuals who were characterized for neurocognitive functioning and had paired CSF and blood plasma samples available. To avoid issues with repeated sampling, we generated population-based HIV-1 tat sequences from each compartment and evaluated these data using a battery of phylogenetic, statistical, and machine learning tools. These analyses identified position HXB2 5905 within the cysteine-rich domain of tat as a signature of CSF-derived HIV-1, and a higher number of mixed bases in CSF, as measure of diversity, was associated with HIV-associated neurocognitive disorder. Since identified mutations were synonymous, we evaluated the predicted secondary RNA structures, which showed that this mutation altered secondary structure. As a measure of divergence, the genetic distance between the blood and CSF-derived tat was inversely correlated with current and nadir CD4+ T cell counts. These data suggest that specific HIV-1 features of tat influence neurotropism and neurocognitive impairment. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF NEUROVIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyo Jeong Kim | - |
dc.contributor.googleauthor | Shin Hye Kim | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Young-Mock Lee | - |
dc.contributor.googleauthor | Kyo Yeon Koo | - |
dc.contributor.googleauthor | Jin Sung Lee | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.identifier.doi | 10.1007/s13365-011-0059-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01641 | - |
dc.identifier.eissn | 1538-2443 | - |
dc.identifier.pmid | HIV ; Central nervous system ; tat ; Compartmentalization | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | Central nervous system | - |
dc.subject.keyword | tat | - |
dc.subject.keyword | Compartmentalization | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROVIROLOGY, Vol.18(2) : 81-90, 2012 | - |
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