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Resistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36

DC FieldValueLanguage
dc.contributor.author배일권-
dc.contributor.author신소연-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author김주원-
dc.contributor.author김준명-
dc.date.accessioned2014-12-19T17:11:54Z-
dc.date.available2014-12-19T17:11:54Z-
dc.date.issued2012-
dc.identifier.issn0022-2615-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90959-
dc.description.abstractThis study investigated the molecular mechanisms of carbapenem resistance in clinical isolates of Klebsiella pneumoniae from Korea and the clinical outcomes of resistant K. pneumoniae infection. Sixteen K. pneumoniae isolates showing resistance to carbapenems collected from a tertiary-care hospital were examined for the mechanisms of carbapenem resistance. PCR and sequencing experiments detected the blaDHA-1 AmpC β-lactamase gene in all 16 clinical isolates, whilst the bla genes of extended-spectrum β-lactamases were detected in 12 of 16 isolates. SDS-PAGE experiments indicated that all the isolates lacked the 35 kDa and/or 36 kDa outer-membrane proteins (OMPs). Sequence analysis of the corresponding OMP genes revealed various alterations. PFGE analysis demonstrated that there were no major clonal relationships among the K. pneumoniae isolates. However, multilocus sequence typing experiments showed that all isolates shared the same sequence type (ST), ST11, except for one isolate of ST48. The crude mortality rate of infected patients was 81.8 %. Carbapenem resistance was mainly due to a combination of DHA-1 AmpC β-lactamase coupled with the loss of OmpK35 and/or OmpK36 and was associated with poor clinical outcome.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Medical Microbiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleResistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorSo Youn Shin-
dc.contributor.googleauthorIl Kwon Bae-
dc.contributor.googleauthorJuwon Kim-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.1099/jmm.0.037036-0-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01802-
dc.contributor.localIdA02116-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA00943-
dc.contributor.localIdA00953-
dc.relation.journalcodeJ01583-
dc.identifier.urlhttp://jmm.sgmjournals.org/content/61/2/239.short-
dc.contributor.alternativeNameBae, Il Kwon-
dc.contributor.alternativeNameShin, So Youn-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameKim, Ju Won-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.affiliatedAuthorBae, Il Kwon-
dc.contributor.affiliatedAuthorShin, So Youn-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorKim, Ju Won-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.citation.volume61-
dc.citation.number2-
dc.citation.startPage239-
dc.citation.endPage245-
dc.identifier.bibliographicCitationJournal of Medical Microbiology, Vol.61(2) : 239-245, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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