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Clinical results of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation in children with advanced stage rhabdomyosarcomastage rhabdomyosarcoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김남균 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 김효선 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 유철주 | - |
dc.date.accessioned | 2014-12-19T17:10:24Z | - |
dc.date.available | 2014-12-19T17:10:24Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90910 | - |
dc.description.abstract | Regardless of improvement in cure of Rhabdomyosarcoma (RMS), the results in treatment of advanced stage of RMS in children are still dismal. Recently, high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (HDC/APBSCT) has been tried to manage the advanced high-risk RMS patients. We investigated the effectiveness of HDC/APBSCT by reviewing the clinical records of high-risk pediatric RMS patients in single institute database. Over twenty years, 37 patients were diagnosed as RMS with high-risk at the time of first diagnosis. These patients were classified as two groups according to treatment method. The first group was HDC/APBSCT and the other was conventional multi-agent chemotherapy group. Differences of clinical results between the two groups were analyzed. The median age of patients was 5 yr, ranging from 6 months to 15 yr. The 5-yr event free survival rate (EFS) of all patients was 24.8% ± 4.8%. HDC/APBSCT group and conventional multi-agent chemotherapy group were 41.3% ± 17.8% and 16.7% ± 7.6% for 5-yr EFS, respectively (P = 0.023). There was a significant difference in the result of HDC/APBSCT between complete remission or very good partial response group and poor response group (50% ± 20.4% vs 37.5% ± 28.6%, P = 0.018). HDC/APBSCT can be a promising treatment modality in high-risk RMS patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Carboplatin/administration & dosage | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Etoposide/administration & dosage | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ifosfamide/administration & dosage | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Peripheral Blood Stem Cell Transplantation* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Rhabdomyosarcoma/drug therapy* | - |
dc.subject.MESH | Rhabdomyosarcoma/mortality | - |
dc.subject.MESH | Rhabdomyosarcoma/pathology | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical results of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation in children with advanced stage rhabdomyosarcomastage rhabdomyosarcoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Nam Kyun Kim | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.contributor.googleauthor | Hyun Ok Kim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.identifier.doi | 22969254 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00355 | - |
dc.contributor.localId | A01122 | - |
dc.contributor.localId | A01201 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 22969254 | - |
dc.subject.keyword | Bone Marrow Transplantation | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Children | - |
dc.subject.keyword | Rhabdomyosarcoma | - |
dc.contributor.alternativeName | Kim, Nam Kyun | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.alternativeName | Kim, Hyo Sun | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ok | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Sun | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.citation.volume | 27 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1066 | - |
dc.citation.endPage | 1072 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(9) : 1066-1072, 2012 | - |
dc.identifier.rimsid | 33208 | - |
dc.type.rims | ART | - |
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