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Optimal baseline prostate-specific antigen level to distinguish risk of prostate cancer in healthy men between 40 and 69 years of age

DC Field Value Language
dc.contributor.author박경기-
dc.contributor.author이승환-
dc.contributor.author정병하-
dc.contributor.author최영득-
dc.date.accessioned2014-12-19T17:09:34Z-
dc.date.available2014-12-19T17:09:34Z-
dc.date.issued2012-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90884-
dc.description.abstractThe present study evaluated optimal baseline prostate-specific antigen (PSA) level at different ages in order to determine the risk of developing prostate cancer (CaP). We analyzed 6,651 Korean men, aged 40-69 yr. The serum PSA levels for these men were measured at one institute from 2000 to 2004 and were determined to be between 0-4 ng/mL. Patients were divided into 4 groups of 25th-percentile intervals, based on initial PSA level. Of these, the group with an increased risk was selected, and the optimal value was determined by the maximal area under a receiver-operating characteristic curve within the selected group. The risk of CaP diagnosis was evaluated by Cox regression. The mean follow-up period was 8.3 yr. CaP was detected in 27 of the 6,651 subjects. CaP detection rate was increased according to age. The optimal PSA value to distinguish the risk of CaP was 2.0 ng/mL for 50- to 69-yr-olds. Patients with a baseline PSA level greater than the optimal value had a 27.78 fold increase in the prostate cancer risk. Baseline PSA values are useful for determining the risk of developing CaP in Korean men for 50- and 69-yr-old. We suggest that PSA testing intervals be modified based on their baseline PSA levels.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHArea Under Curve-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProstate-Specific Antigen/blood*-
dc.subject.MESHProstatic Neoplasms/diagnosis*-
dc.subject.MESHRisk Factors-
dc.titleOptimal baseline prostate-specific antigen level to distinguish risk of prostate cancer in healthy men between 40 and 69 years of age-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorKyung Kgi Park-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi10.3346/jkms.2012.27.1.40-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02938-
dc.contributor.localIdA01419-
dc.contributor.localIdA03607-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid22219612-
dc.subject.keywordAsian Continental Ancestry Group-
dc.subject.keywordProstate Neoplasm-
dc.subject.keywordProstate-Specific Antigen-
dc.subject.keywordScreening-
dc.contributor.alternativeNamePark, Kyung Kgi-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorPark, Kyung Kgi-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.citation.volume27-
dc.citation.number1-
dc.citation.startPage40-
dc.citation.endPage45-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(1) : 40-45, 2012-
dc.identifier.rimsid34587-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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