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Serial optical coherence tomography-based observation of strut coverage on drug-eluting stent crossing side-branch vessels

Authors
 Seung-Yul Lee  ;  Jung-Sun Kim  ;  Dong-Ho Shin  ;  Byeong-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 JOURNAL OF INVASIVE CARDIOLOGY, Vol.24(11) : 569-573, 2012 
Journal Title
 JOURNAL OF INVASIVE CARDIOLOGY 
ISSN
 1042-3931 
Issue Date
2012
MeSH
Aged ; Coronary Restenosis/epidemiology ; Coronary Restenosis/prevention & control* ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Neointima/pathology ; Paclitaxel ; Percutaneous Coronary Intervention/instrumentation* ; Percutaneous Coronary Intervention/methods* ; Retrospective Studies ; Sirolimus/analogs & derivatives ; Time Factors ; Tomography, Optical Coherence/methods*
Keywords
optical coherence tomography ; stent
Abstract
BACKGROUND: Serial changes in strut coverage of drug-eluting stents (DESs), which are placed across side-branch vessels, remain unclear. METHODS: The changes in strut coverage of DESs crossing side-branch vessels (size ≥2.0 mm) were serially evaluated by optical coherence tomography (OCT) in 30 patients at 9 months and 2 years after the index DES implantation. DESs were paclitaxel-eluting stents (PESs), sirolimus-eluting stents (SESs), and zotarolimus-eluting stents (ZESs), each in 10 patients. Measured neointimal hyperplasia (NIH) thickness of 0 μm on OCT was defined as an uncovered strut. RESULTS: The percentage of uncovered side-branch struts significantly decreased from 55.7 ± 39.9% to 36.6 ± 32.0% (P<.0001) on serial follow-up: PES, 93.4 ± 10.5% to 67.6 ± 24.2%, P=.018; SES, 47.5 ± 34.4% to 29.6 ± 24.1%, P=.036; and ZES, 26.2 ± 34.8% to 12.4 ± 19.0%, P=.028. Among covered side-branch struts, the overall percentage of struts with NIH thickness more than 30 μm significantly increased from 36.3 ± 37.4% to 51.0 ± 36.0% (P<.0001). However, compared to other DES types, a significant increase in relatively thin NIH (0 to 30 μm) was observed in PESs (1.6 ± 3.4% to 17.4 ± 16.0%; P=.018). CONCLUSION: Serial follow-up OCT examination showed a significant decrease in the percentage of uncovered side-branch struts, and the coverage pattern differed with DES type
Full Text
http://invasivecardiology.com/articles/serial-optical-coherence-tomography-based-observation-strut-coverage-drug-eluting-stent
DOI
23117310
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Lee, Seung Yul(이승율)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90864
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