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Metaplastic breast cancer: clinicopathological features and its prognosis
DC Field | Value | Language |
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dc.contributor.author | 손주혁 | - |
dc.date.accessioned | 2014-12-19T17:03:41Z | - |
dc.date.available | 2014-12-19T17:03:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90703 | - |
dc.description.abstract | AIMS: The prognosis of metaplastic breast cancer (MBC) is reportedly worse than that of triple-negative invasive ductal carcinoma (TN-IDC), but the determinants of poor prognosis are not yet known. METHODS: Patients from two Korean cancer centres were included in this study (67 MBC and 520 TN-IDC). Characteristics of the two disease groups, including clinical parameters, histological features, chemoresponsiveness, disease recurrence and survival estimates, were evaluated. RESULTS: MBC presented with larger tumours, more frequent distant metastasis and higher histological grade compared with TN-IDC (p<0.001). All but nine patients with MBC had triple-negative disease. Disease-free survival and overall survival (OS) of MBC were worse than TN-IDC (p<0.001). Multivariable analysis of disease-free survival revealed MBC type as an independent prognostic factor (HR 2.53; 95% CI 1.32 to 4.84) along with lymph node metastasis and implementation of breast conserving surgery. For OS, MBC type remained a significant prognostic factor (HR 2.56; 95% CI 1.18 to 5.54). Chemoresponsiveness of MBC and TN-IDC were similar in both neoadjuvant (p=1.000) and advanced disease settings (p=0.508). For a given MBC type, risk factors for disease recurrence included the presence of a squamous component (HR 4.0; 95% CI 1.46 to 10.99) and lymph node metastasis (HR 4.76; 95% CI 1.67 to 13.60); the risk factor for OS was initial distant metastasis (HR 10.77; 95% CI 2.59 to 44.76). CONCLUSIONS: MBC had worse survival outcomes compared with TN-IDC. Poor prognosis for MBC was likely caused by frequent recurrence with high initial stage and the unique biology of MBC itself. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Breast/pathology* | - |
dc.subject.MESH | Breast Neoplasms/chemistry | - |
dc.subject.MESH | Breast Neoplasms/drug therapy | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/chemistry | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/drug therapy | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/mortality | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/secondary* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Nodes/pathology | - |
dc.subject.MESH | Mastectomy, Segmental/methods | - |
dc.subject.MESH | Metaplasia | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Receptor, ErbB-2/analysis | - |
dc.subject.MESH | Receptors, Estrogen/analysis | - |
dc.subject.MESH | Receptors, Progesterone/analysis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Metaplastic breast cancer: clinicopathological features and its prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyewon Lee | - |
dc.contributor.googleauthor | So-Youn Jung | - |
dc.contributor.googleauthor | Jae Yun Ro | - |
dc.contributor.googleauthor | Youngmee Kwon | - |
dc.contributor.googleauthor | Joo Hyuk Sohn | - |
dc.contributor.googleauthor | In Hae Park | - |
dc.contributor.googleauthor | Keun Seok Lee | - |
dc.contributor.googleauthor | Seeyoun Lee | - |
dc.contributor.googleauthor | Seok Won Kim | - |
dc.contributor.googleauthor | Han Sung Kang | - |
dc.contributor.googleauthor | Kyoung Lan Ko | - |
dc.contributor.googleauthor | Jungsil Ro | - |
dc.identifier.doi | 22412048 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01995 | - |
dc.relation.journalcode | J01334 | - |
dc.identifier.eissn | 1472-4146 | - |
dc.identifier.pmid | 22412048 | - |
dc.identifier.url | http://jcp.bmj.com/content/65/5/441.long | - |
dc.subject.keyword | Biomarkers, Tumor/analysis | - |
dc.subject.keyword | Breast/pathology* | - |
dc.subject.keyword | Breast Neoplasms/chemistry | - |
dc.subject.keyword | Breast Neoplasms/drug therapy | - |
dc.subject.keyword | Breast Neoplasms/mortality | - |
dc.subject.keyword | Breast Neoplasms/pathology* | - |
dc.subject.keyword | Carcinoma, Ductal, Breast/chemistry | - |
dc.subject.keyword | Carcinoma, Ductal, Breast/drug therapy | - |
dc.subject.keyword | Carcinoma, Ductal, Breast/mortality | - |
dc.subject.keyword | Carcinoma, Ductal, Breast/secondary* | - |
dc.subject.keyword | Disease-Free Survival | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Lymph Nodes/pathology | - |
dc.subject.keyword | Mastectomy, Segmental/methods | - |
dc.subject.keyword | Metaplasia | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Neoadjuvant Therapy | - |
dc.subject.keyword | Neoplasm Recurrence, Local | - |
dc.subject.keyword | Neoplasm Staging | - |
dc.subject.keyword | Receptor, ErbB-2/analysis | - |
dc.subject.keyword | Receptors, Estrogen/analysis | - |
dc.subject.keyword | Receptors, Progesterone/analysis | - |
dc.subject.keyword | Republic of Korea/epidemiology | - |
dc.subject.keyword | Survival Rate | - |
dc.contributor.alternativeName | Sohn, Joo Hyuk | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyuk | - |
dc.citation.volume | 65 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 441 | - |
dc.citation.endPage | 446 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PATHOLOGY, Vol.65(5) : 441-446, 2012 | - |
dc.identifier.rimsid | 33480 | - |
dc.type.rims | ART | - |
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