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Gender-dependent skeletal effects of vitamin D deficiency in a younger generation

DC FieldValueLanguage
dc.contributor.author김경민-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.date.accessioned2014-12-19T17:02:58Z-
dc.date.available2014-12-19T17:02:58Z-
dc.date.issued2012-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90681-
dc.description.abstractCONTEXT: The major health threats caused by vitamin D deficiency in the young generation have not been fully elucidated. OBJECTIVE: The aim of this study was to investigate skeletal and nonskeletal effects of vitamin D deficiency and to study the optimal level of serum 25-hydroxyvitamin D [25(OH)D] in young people. DESIGN AND SETTING: The Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) was conducted in 2008-2009. PARTICIPANTS: A total of 4276 people (1926 men and 2350 women) aged 10-40 yr were selected from 16 administrative districts of South Korea. MAIN OUTCOME MEASURES: We measured age-specific changes in bone mineral density (BMD) according to serum 25(OH)D. RESULTS: Serum 25(OH)D was less than 25 nmol/liter in 18.8% of participants, 25 to less than 50 nmol/liter in 50.0%, 50 to less than 75 nmol/liter in 27.0%, and 75 nmol/liter or greater in 4.2%. Vitamin D deficiency was more frequent in women than in men. There were gender differences in the skeletal effects of vitamin D deficiency. In men between 10 and 22 yr old, BMD was significantly higher in the vitamin D-sufficient group, and in men between 23 and 40 yr old, a positive correlation between serum 25(OH)D and BMD was observed. However, in women, we could not find significant differences in BMD according to vitamin D status. Vitamin D deficiency in younger generations had no remarkable effects on most nonskeletal parameters or on the prevalence of concomitant diseases except for rheumatoid arthritis. CONCLUSIONS: Vitamin D plays an essential role in skeletal health of young people. Moreover, the presence of gender-dependent skeletal effects was an important observation of this study. Reassurance of serum 25(OH)D up to 20-30 ng/ml or higher is necessary, especially during the modeling phase in men.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1995~2004-
dc.relation.isPartOfJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge Distribution-
dc.subject.MESHBone Density/physiology*-
dc.subject.MESHBone Remodeling/physiology*-
dc.subject.MESHBone and Bones/physiology-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNutrition Surveys/statistics & numerical data-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSex Characteristics*-
dc.subject.MESHSex Distribution-
dc.subject.MESHVitamin D/analogs & derivatives*-
dc.subject.MESHVitamin D/blood-
dc.subject.MESHVitamin D Deficiency/epidemiology*-
dc.subject.MESHVitamin D Deficiency/physiopathology*-
dc.subject.MESHYoung Adult-
dc.titleGender-dependent skeletal effects of vitamin D deficiency in a younger generation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Soo Lim-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi22442269-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00295-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.relation.journalcodeJ01318-
dc.identifier.eissn1945-7197-
dc.identifier.pmid22442269-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAge Distribution-
dc.subject.keywordBone Density/physiology*-
dc.subject.keywordBone Remodeling/physiology*-
dc.subject.keywordBone and Bones/physiology-
dc.subject.keywordChild-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordNutrition Surveys/statistics & numerical data-
dc.subject.keywordRepublic of Korea/epidemiology-
dc.subject.keywordSex Characteristics*-
dc.subject.keywordSex Distribution-
dc.subject.keywordVitamin D/analogs & derivatives*-
dc.subject.keywordVitamin D/blood-
dc.subject.keywordVitamin D Deficiency/epidemiology*-
dc.subject.keywordVitamin D Deficiency/physiopathology*-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorKim, Kyung Min-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.citation.volume97-
dc.citation.number6-
dc.citation.startPage1995-
dc.citation.endPage2004-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.97(6) : 1995-2004, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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