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Preservation of renal function by thyroid hormone replacement therapy in chronic kidney disease patients with subclinical hypothyroidism

DC FieldValueLanguage
dc.contributor.author오형중-
dc.contributor.author강신욱-
dc.contributor.author유태현-
dc.contributor.author구향모-
dc.contributor.author이미정-
dc.contributor.author김승준-
dc.contributor.author한승혁-
dc.contributor.author김형래-
dc.contributor.author한재현-
dc.contributor.author도화미-
dc.contributor.author박정탁-
dc.date.accessioned2014-12-19T17:02:56Z-
dc.date.available2014-12-19T17:02:56Z-
dc.date.issued2012-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90680-
dc.description.abstractCONTEXT: Subclinical hypothyroidism is not a rare condition, but the use of thyroid hormone to treat subclinical hypothyroidism is an issue of debate. OBJECTIVE: This study was undertaken to investigate the impact of thyroid hormone therapy on the changes in estimated glomerular filtration rate (eGFR) in subclinical hypothyroidism patients with stage 2-4 chronic kidney disease. PATIENTS: A total of 309 patients were included in the final analysis. MAIN OUTCOME MEASURE: The changes in eGFR over time were compared between patients with and without thyroid hormone replacement therapy using a linear mixed model. Kaplan-Meier curves were constructed to determine the effect of thyroid hormone on renal outcome, a reduction of eGFR by 50%, or end-stage renal disease. The independent prognostic value of subclinical hypothyroidism treatment for renal outcome was ascertained by multivariate Cox regression analysis. RESULTS: Among the 309 patients, 180 (58.3%) took thyroid hormone (treatment group), whereas 129 (41.7%) did not (nontreatment group). During the mean follow-up duration of 34.8 ± 24.3 months, the overall rate of decline in eGFR was significantly greater in the nontreatment group compared to the treatment group (-5.93 ± 1.65 vs. -2.11 ± 1.12 ml/min/yr/1.73 m(2); P = 0.04). Moreover, a linear mixed model revealed that there was a significant difference in the rates of eGFR decline over time between the two groups (P < 0.01). Kaplan-Meier analysis also showed that renal event-free survival was significantly lower in the nontreatment group (P < 0.01). In multivariate Cox regression analysis, thyroid hormone replacement therapy was found to be an independent predictor of renal outcome (hazard ratio, 0.28; 95% CI, 0.12-0.68; P = 0.01). CONCLUSION: Thyroid hormone therapy not only preserved renal function better, but was also an independent predictor of renal outcome in chronic kidney disease patients with subclinical hypothyroidism.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Pressure-
dc.subject.MESHChronic Disease-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHormone Replacement Therapy*-
dc.subject.MESHHumans-
dc.subject.MESHHypothyroidism/drug therapy*-
dc.subject.MESHHypothyroidism/physiopathology-
dc.subject.MESHIodide Peroxidase/immunology-
dc.subject.MESHKidney Diseases/complications*-
dc.subject.MESHKidney Diseases/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHThyroid Hormones/therapeutic use*-
dc.subject.MESHThyrotropin/blood-
dc.titlePreservation of renal function by thyroid hormone replacement therapy in chronic kidney disease patients with subclinical hypothyroidism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorHyoung Rae Kim-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi22723335-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02417-
dc.contributor.localIdA00053-
dc.contributor.localIdA02526-
dc.contributor.localIdA00203-
dc.contributor.localIdA04304-
dc.contributor.localIdA01147-
dc.contributor.localIdA04320-
dc.contributor.localIdA01315-
dc.contributor.localIdA01654-
dc.contributor.localIdA02097-
dc.contributor.localIdA00659-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ01318-
dc.identifier.eissn1945-7197-
dc.identifier.pmid22723335-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordBlood Pressure-
dc.subject.keywordChronic Disease-
dc.subject.keywordFemale-
dc.subject.keywordGlomerular Filtration Rate-
dc.subject.keywordHormone Replacement Therapy*-
dc.subject.keywordHumans-
dc.subject.keywordHypothyroidism/drug therapy*-
dc.subject.keywordHypothyroidism/physiopathology-
dc.subject.keywordIodide Peroxidase/immunology-
dc.subject.keywordKidney Diseases/complications*-
dc.subject.keywordKidney Diseases/physiopathology-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordThyroid Hormones/therapeutic use*-
dc.subject.keywordThyrotropin/blood-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKim, Hyoung Rae-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKim, Hyoung Rae-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.citation.volume97-
dc.citation.number8-
dc.citation.startPage2732-
dc.citation.endPage2740-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.97(8) : 2732-2740, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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