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Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author김승일-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박지민-
dc.contributor.author박형석-
dc.contributor.author조정훈-
dc.date.accessioned2014-12-19T17:00:05Z-
dc.date.available2014-12-19T17:00:05Z-
dc.date.issued2012-
dc.identifier.issn0368-2811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90593-
dc.description.abstractOBJECTIVE: This study investigated the incidence and clinical significance of homeodomain-interacting protein kinase 1 expression in breast cancer patients. METHODS: We investigated immunohistochemical homeodomain-interacting protein kinase 1 expression from tissue microarrays of 1032 patients. The association of homeodomain-interacting protein kinase 1 expression pattern, clinicopathologic factors and survival outcome was evaluated. Tumors with ≥10% stained cells were considered positive for homeodomain-interacting protein kinase 1. RESULTS: Non-cancerous breast tissue, pTis and pT1mic lesions did not show homeodomain-interacting protein kinase 1 expression at any sites. Of the 859 invasive tumors, 124 (14.4%) showed homeodomain-interacting protein kinase 1 expression with three different expression patterns: cytoplasmic (2.4%), nuclear (6.3%), and both cytoplasmic and nuclear (5.7%). Cytoplasmic homeodomain-interacting protein kinase 1-positive tumors showed distinctive features such as fewer nodal metastases, but were frequently Grade III, estrogen receptor-negative, progesterone receptor-negative, HER2-positive, highly proliferative and molecular apocrine tumors. No significant difference in clinicopathologic features was identified between negative and nuclear homeodomain-interacting protein kinase 1-positive tumors. Both cytoplasmic and nuclear HIPK1-positive tumors represent frequent small size, node negativity and moderately differentiated features. Survival was not significantly different by homeodomain-interacting protein kinase 1 expression patterns. CONCLUSIONS: Homeodomain-interacting protein kinase 1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear. Although the mechanism is not certain, the subcellular localization of HIPK1 expression is associated with tumor histopathologic characteristics and different functions.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJAPANESE JOURNAL OF CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHBreast Neoplasms/epidemiology*-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCell Nucleus/metabolism-
dc.subject.MESHCytoplasm/metabolism-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHProtein-Serine-Threonine Kinases/metabolism*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTissue Array Analysis-
dc.titleHomeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorJi Min Park-
dc.contributor.googleauthorJung Hoon Cho-
dc.contributor.googleauthorHyung Seok Park-
dc.identifier.doi23071292-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA00658-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01685-
dc.contributor.localIdA01753-
dc.contributor.localIdA03906-
dc.relation.journalcodeJ01207-
dc.identifier.eissn1465-3621-
dc.identifier.pmid23071292-
dc.subject.keywordbreast cancer-
dc.subject.keywordhomeodomain-interacting protein kinase 1-
dc.subject.keywordmolecular apocrine tumor-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNamePark, Ji Min-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameCho, Jung Hoon-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorPark, Ji Min-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorCho, Jung Hoon-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume42-
dc.citation.number12-
dc.citation.startPage1138-
dc.citation.endPage1145-
dc.identifier.bibliographicCitationJAPANESE JOURNAL OF CLINICAL ONCOLOGY, Vol.42(12) : 1138-1145, 2012-
dc.identifier.rimsid32857-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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