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Quantitative and qualitative changes in DES-related neointimal tissue based on serial OCT
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 신동호 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2014-12-19T16:59:48Z | - |
dc.date.available | 2014-12-19T16:59:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1936-878X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90585 | - |
dc.description.abstract | OBJECTIVES: The study evaluated serial quantitative and qualitative changes in vascular responses to drug-eluting stents (DES) using optical coherence tomography (OCT). BACKGROUND: Serial changes in stent strut coverage and neointima characteristics in DES-treated lesions have not been sufficiently investigated using OCT. METHODS: Serial OCT was performed in 72 patients with 76 DES-treated lesions at 9 months and 2 years after DES implantation (sirolimus-eluting stent, n = 23; paclitaxel-eluting stent, n = 20; zotarolimus-eluting stent, n = 25; everolimus-eluting stent, n = 8). Serial changes in quantitative parameters (neointimal thickness, stent strut coverage, and apposition at each strut) and qualitative characteristics of the neointima were evaluated. RESULTS: Mean neointimal thickness significantly increased from 164 μm to 214 μm between 9 months and 2 years (p < 0.001), and the percentage of uncovered stent struts significantly decreased (from 4.4% to 2.3%, p < 0.001). Completely covered lesions were more frequently observed at 2 years (44.7% vs. 59.2%, p = 0.07). However, the percentage of malapposed struts (0.6% vs. 0.9%, p = 0.24) and incidence of intracoronary thrombi (10.5% vs. 9.2%, p > 0.99) were similar. On qualitative evaluation of neointimal morphology, lipid-laden neointima (27.6% vs. 14.5%, p = 0.009) and thin-cap neoatheroma (13.2% vs. 3.9%, p = 0.07) were more frequently detected at 2-year follow-up compared with 9 months. In matched cross-sectional evaluation, the change of neointimal morphology from homogeneous to heterogeneous or lipid-laden pattern was observed in 23 (30.3%) of 76 lesions. There was a significant increase in percent neointimal hyperplasia cross-sectional area in those lesions. CONCLUSIONS: This OCT study suggested that neointimal coverage improved from 9 months to 2 years without significant changes in the incidence of malapposed struts and intracoronary thrombus. Additionally, in-stent neoatherosclerosis including transformation to lipid-laden neointima might progress during extended follow-up periods after DES implantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JACC-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiovascular Agents/administration & dosage | - |
dc.subject.MESH | Coronary Thrombosis/etiology | - |
dc.subject.MESH | Coronary Thrombosis/pathology | - |
dc.subject.MESH | Coronary Vessels/pathology* | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Everolimus | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neointima* | - |
dc.subject.MESH | Paclitaxel/administration & dosage | - |
dc.subject.MESH | Percutaneous Coronary Intervention/adverse effects | - |
dc.subject.MESH | Percutaneous Coronary Intervention/instrumentation* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Sirolimus/administration & dosage | - |
dc.subject.MESH | Sirolimus/analogs & derivatives | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, Optical Coherence* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Quantitative and qualitative changes in DES-related neointimal tissue based on serial OCT | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Dong-Ho Shin | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 23153915 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J01192 | - |
dc.identifier.eissn | 1876-7591 | - |
dc.identifier.pmid | 23153915 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1936878X12007449 | - |
dc.subject.keyword | neointima | - |
dc.subject.keyword | optical coherence tomography | - |
dc.subject.keyword | stent | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.citation.volume | 5 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1147 | - |
dc.citation.endPage | 1155 | - |
dc.identifier.bibliographicCitation | JACC-CARDIOVASCULAR IMAGING, Vol.5(11) : 1147-1155, 2012 | - |
dc.identifier.rimsid | 32850 | - |
dc.type.rims | ART | - |
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