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Molecular markers predict distant metastases after adjuvant chemoradiation for rectal cancer.
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 김준원 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2014-12-19T16:58:27Z | - |
dc.date.available | 2014-12-19T16:58:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90542 | - |
dc.description.abstract | PURPOSE: The outcomes of adjuvant chemoradiation for locally advanced rectal cancer are nonuniform among patients with matching prognostic factors. We explored the role of molecular markers for predicting the outcome of adjuvant chemoradiation for rectal cancer patients. METHODS AND MATERIALS: The study included 68 patients with stages II to III rectal adenocarcinoma who were treated with total mesorectal excision and adjuvant chemoradiation. Chemotherapy based on 5-fluorouracil and leucovorin was intravenously administered each month for 6-12 cycles. Radiation therapy consisted of 54 Gy delivered in 30 fractions. Immunostaining of surgical specimens for COX-2, EGFR, VEGF, thymidine synthase (TS), and Raf kinase inhibitor protein (RKIP) was performed. RESULTS: The median follow-up was 65 months. Eight locoregional (11.8%) and 13 distant (19.1%) recurrences occurred. Five-year locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) rates for all patients were 83.9%, 78.7%, 66.7%, and 73.8%, respectively. LRFFS was not correlated with TNM stage, surgical margin, or any of the molecular markers. VEGF overexpression was significantly correlated with decreased DMFS (P=.045), while RKIP-positive results were correlated with increased DMFS (P=.025). In multivariate analyses, positive findings for COX-2 (COX-2+) and VEGF (VEGF+) and negative findings for RKIP (RKIP-) were independent prognostic factors for DMFS, DFS, and OS (P=.035, .014, and .007 for DMFS; .021, .010, and <.0001 for DFS; and .004, .012, and .001 for OS). The combination of both COX-2+ and VEGF+ (COX-2+/VEGF+) showed a strong correlation with decreased DFS (P=.007), and the combinations of RKIP+/COX-2- and RKIP+/VEGF- showed strong correlations with improved DFS compared with the rest of the patients (P=.001 and <.0001, respectively). CONCLUSIONS: Molecular markers can be valuable in predicting treatment outcome of adjuvant chemoradiation for rectal cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/chemistry | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/secondary* | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adenocarcinoma/therapy* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/therapeutic use | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant* | - |
dc.subject.MESH | Cyclooxygenase 2/analysis | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/chemistry | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Phosphatidylethanolamine Binding Protein/analysis | - |
dc.subject.MESH | Radiation Dosage | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/analysis | - |
dc.subject.MESH | Rectal Neoplasms/chemistry | - |
dc.subject.MESH | Rectal Neoplasms/mortality | - |
dc.subject.MESH | Rectal Neoplasms/pathology | - |
dc.subject.MESH | Rectal Neoplasms/surgery | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Thymidylate Synthase/analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/analysis | - |
dc.title | Molecular markers predict distant metastases after adjuvant chemoradiation for rectal cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Jun Jeong Choi | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Nam-Kyu Kim | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Ikjae Lee | - |
dc.contributor.googleauthor | Jae Ho Cho | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 22981710 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 22981710 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301612033160 | - |
dc.subject.keyword | Adenocarcinoma/chemistry | - |
dc.subject.keyword | Adenocarcinoma/mortality | - |
dc.subject.keyword | Adenocarcinoma/secondary* | - |
dc.subject.keyword | Adenocarcinoma/surgery | - |
dc.subject.keyword | Adenocarcinoma/therapy* | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Antimetabolites, Antineoplastic/therapeutic use | - |
dc.subject.keyword | Biomarkers, Tumor/analysis* | - |
dc.subject.keyword | Chemoradiotherapy, Adjuvant* | - |
dc.subject.keyword | Cyclooxygenase 2/analysis | - |
dc.subject.keyword | Disease-Free Survival | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Fluorouracil/therapeutic use | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Neoplasm Recurrence, Local/chemistry | - |
dc.subject.keyword | Neoplasm Recurrence, Local/mortality | - |
dc.subject.keyword | Phosphatidylethanolamine Binding Protein/analysis | - |
dc.subject.keyword | Radiation Dosage | - |
dc.subject.keyword | Receptor, Epidermal Growth Factor/analysis | - |
dc.subject.keyword | Rectal Neoplasms/chemistry | - |
dc.subject.keyword | Rectal Neoplasms/mortality | - |
dc.subject.keyword | Rectal Neoplasms/pathology | - |
dc.subject.keyword | Rectal Neoplasms/surgery | - |
dc.subject.keyword | Rectal Neoplasms/therapy* | - |
dc.subject.keyword | Thymidylate Synthase/analysis | - |
dc.subject.keyword | Treatment Outcome | - |
dc.subject.keyword | Vascular Endothelial Growth Factor A/analysis | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.citation.volume | 84 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 577 | - |
dc.citation.endPage | 584 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.84(5) : 577-584, 2012 | - |
dc.identifier.rimsid | 32823 | - |
dc.type.rims | ART | - |
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