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A multimodal approach including craniospinal irradiation improves the treatment outcome of high-risk intracranial nongerminomatous germ cell tumors

DC Field Value Language
dc.contributor.author김동석-
dc.contributor.author김준원-
dc.contributor.author서창옥-
dc.contributor.author심규원-
dc.contributor.author원성철-
dc.contributor.author유철주-
dc.contributor.author조재호-
dc.date.accessioned2014-12-19T16:58:12Z-
dc.date.available2014-12-19T16:58:12Z-
dc.date.issued2012-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90534-
dc.description.abstractPURPOSE: To evaluate whether a multimodal approach including craniospinal irradiation (CSI) improves treatment outcome in nongerminomatous germ cell tumor (NGGCT) patients. METHODS AND MATERIALS: We reviewed the records of 32 patients with NGGCTs. Fourteen patients belonged to the intermediate prognosis group (immature teratoma, teratoma with malignant transformation, and mixed tumors mainly composed of germinoma or teratoma), and 18 patients belonged to the poor prognosis group (other highly malignant tumors). Patients with pure germinoma or mature teratoma were excluded from this study. Nineteen patients were treated with a combination of surgery, chemotherapy, and radiotherapy (RT); 9 patients received chemotherapy plus RT; 3 patients received surgery plus RT; and 1 patient received RT alone. Twenty-seven patients received CSI with a median of 36 Gy (range, 20-41 Gy) plus focal boost of 18-30.6 Gy, and 5 patients received whole-brain RT (WBRT) (20-36 Gy) or focal RT (50.4-54 Gy). The rate of total and subtotal resection was 71.9%. The median follow-up for surviving patients was 121 months. RESULTS: Treatment failed in 7 patients. Three of the 5 patients who received focal RT or WBRT had local failure. Four cerebrospinal fluid (CSF) failures occurred after CSI. No failure occurred in the intermediate prognosis group. Ten-year recurrence-free survival (RFS) and overall survival (OS) for all patients were 77.6% and 74.6%, respectively. Ten-year RFS for the intermediate and poor prognosis groups were 100% and 61.1%, respectively (p = 0.012). OS for the two groups were 85.1% and 66.7%, respectively (p = 0.215). Tumor histology and CSI were significant prognostic factors for RFS, and CSI was significantly associated with OS. CONCLUSIONS: A multimodal approach was effective for treating NGGCTs. CSI should be considered for patients with poor prognostic histology-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHBrain Neoplasms/cerebrospinal fluid-
dc.subject.MESHBrain Neoplasms/mortality-
dc.subject.MESHBrain Neoplasms/pathology-
dc.subject.MESHBrain Neoplasms/therapy*-
dc.subject.MESHCause of Death-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChoriocarcinoma/cerebrospinal fluid-
dc.subject.MESHChoriocarcinoma/mortality-
dc.subject.MESHChoriocarcinoma/pathology-
dc.subject.MESHChoriocarcinoma/therapy-
dc.subject.MESHCombined Modality Therapy/methods-
dc.subject.MESHCraniospinal Irradiation/methods*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEndodermal Sinus Tumor/cerebrospinal fluid-
dc.subject.MESHEndodermal Sinus Tumor/mortality-
dc.subject.MESHEndodermal Sinus Tumor/pathology-
dc.subject.MESHEndodermal Sinus Tumor/therapy-
dc.subject.MESHFemale-
dc.subject.MESHGerminoma/cerebrospinal fluid-
dc.subject.MESHGerminoma/mortality-
dc.subject.MESHGerminoma/pathology-
dc.subject.MESHGerminoma/therapy-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeoplasm Recurrence, Local/mortality-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasms, Germ Cell and Embryonal/cerebrospinal fluid-
dc.subject.MESHNeoplasms, Germ Cell and Embryonal/mortality-
dc.subject.MESHNeoplasms, Germ Cell and Embryonal/pathology-
dc.subject.MESHNeoplasms, Germ Cell and Embryonal/therapy*-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHSalvage Therapy/methods-
dc.subject.MESHSalvage Therapy/mortality-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTeratoma/cerebrospinal fluid-
dc.subject.MESHTeratoma/mortality-
dc.subject.MESHTeratoma/pathology-
dc.subject.MESHTeratoma/therapy-
dc.subject.MESHYoung Adult-
dc.titleA multimodal approach including craniospinal irradiation improves the treatment outcome of high-risk intracranial nongerminomatous germ cell tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorWoo Chul Kim-
dc.contributor.googleauthorJae Ho Cho-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorKyu-Won Shim-
dc.contributor.googleauthorChul Joo Lyu-
dc.contributor.googleauthorSung Chul Won-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.1016/j.ijrobp.2011.12.077-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00402-
dc.contributor.localIdA00958-
dc.contributor.localIdA01919-
dc.contributor.localIdA02187-
dc.contributor.localIdA02434-
dc.contributor.localIdA02524-
dc.contributor.localIdA03901-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid22420971-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S036030161103803X-
dc.subject.keywordNongerminomatous germ cell tumor-
dc.subject.keywordMultimodal approach-
dc.subject.keywordCraniospinal irradiation-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameShim, Kyu Won-
dc.contributor.alternativeNameWon, Sung Chul-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Jun Won-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorShim, Kyu Won-
dc.contributor.affiliatedAuthorWon, Sung Chul-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.citation.volume84-
dc.citation.number3-
dc.citation.startPage625-
dc.citation.endPage631-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.84(3) : 625-631, 2012-
dc.identifier.rimsid32820-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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