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Association of human adenovirus-36 in overweight Korean adults.

Authors
 H-N Na  ;  J Kim  ;  HS Lee  ;  KW Shim  ;  H Kimm  ;  SH Jee  ;  I Jo  ;  J-H Nam 
Citation
 INTERNATIONAL JOURNAL OF OBESITY, Vol.36(2) : 281-285, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF OBESITY 
ISSN
 0307-0565 
Issue Date
2012
MeSH
Adenovirus Infections, Human/blood ; Adenovirus Infections, Human/complications* ; Adenovirus Infections, Human/epidemiology* ; Adenovirus Infections, Human/immunology ; Adenoviruses, Human*/immunology ; Adult ; Asian Continental Ancestry Group/statistics & numerical data* ; Biomarkers/blood ; Body Mass Index ; Case-Control Studies ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Obesity/virology ; Odds Ratio ; Overweight/blood ; Overweight/epidemiology ; Overweight/immunology ; Overweight/virology* ; Prevalence ; Republic of Korea/epidemiology ; Risk Factors ; Triglycerides/blood
Keywords
Adenovirus Infections, Human/blood ; Adenovirus Infections, Human/complications* ; Adenovirus Infections, Human/epidemiology* ; Adenovirus Infections, Human/immunology ; Adenoviruses, Human*/immunology ; Adult ; Asian Continental Ancestry Group/statistics & numerical data* ; Biomarkers/blood ; Body Mass Index ; Case-Control Studies ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Obesity/virology ; Odds Ratio ; Overweight/blood ; Overweight/epidemiology ; Overweight/immunology ; Overweight/virology* ; Prevalence ; Republic of Korea/epidemiology ; Risk Factors ; Triglycerides/blood
Abstract
BACKGROUND: Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults. METHODS: A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI<25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay. RESULTS: Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67). CONCLUSION: Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults.
Full Text
http://www.nature.com/ijo/journal/v36/n2/full/ijo2011102a.html
DOI
21587203
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90500
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