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The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment.

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dc.contributor.author윤호근-
dc.contributor.author최효경-
dc.date.accessioned2014-12-19T16:56:58Z-
dc.date.available2014-12-19T16:56:58Z-
dc.date.issued2012-
dc.identifier.issn1107-3756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90494-
dc.description.abstractAlzheimer's disease (AD) is the most common neurodegenerative disease to cause dementia in the elderly. Amyloid β (Aβ)-peptide induced oxidative stress causes the initiation and progression of AD. Recently, new chalcone derivatives termed the Chana series were synthesized. Among them, Chana 1 showed high free radical scavenging activity (72.5%), as measured by a DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. In this study, we investigated the effect of Chana 1 against Aβ-induced cytotoxicity and cognitive deficits. Additionally, we sought to estimate the lethal dose, 50% (LD50) of Chana 1 in mice using an acute oral toxicity test. We found that Chana 1 significantly protected against Aβ-induced neuronal cell death in PC12 cells. Oral administration of Chana 1 at a dose of 50 mg/kg body weight/day significantly improved Aβ-induced learning and memory impairment in mice, as measured in Y-maze and passive avoidance tests. In acute toxicity tests, the LD50 in mice was determined to be 520.44 mg/kg body weight. The data are valuable for future studies and suggest that Chana 1 has therapeutic potential for the management of neurodegenerative disease.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlzheimer Disease/drug therapy*-
dc.subject.MESHAmyloid beta-Peptides/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHChalcone/analogs & derivatives*-
dc.subject.MESHChalcones/pharmacology*-
dc.subject.MESHChalcones/therapeutic use-
dc.subject.MESHChalcones/toxicity-
dc.subject.MESHCognition Disorders/drug therapy*-
dc.subject.MESHLethal Dose 50-
dc.subject.MESHMale-
dc.subject.MESHMaze Learning-
dc.subject.MESHMemory Disorders/drug therapy*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHNeuroprotective Agents/pharmacology-
dc.subject.MESHNeuroprotective Agents/therapeutic use*-
dc.subject.MESHOxidative Stress/drug effects*-
dc.subject.MESHOximes/pharmacology*-
dc.subject.MESHOximes/therapeutic use-
dc.subject.MESHOximes/toxicity-
dc.subject.MESHPC12 Cells-
dc.subject.MESHRandom Allocation-
dc.subject.MESHRats-
dc.titleThe chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorJieun Kwak-
dc.contributor.googleauthorMi-Jeong Kim-
dc.contributor.googleauthorKyung-Chul Choi-
dc.contributor.googleauthorHyo-Kyung Choi-
dc.contributor.googleauthorWoojin Jun-
dc.contributor.googleauthorHyun-Jin Park-
dc.contributor.googleauthorYoo-Hyun Lee-
dc.contributor.googleauthorHo-Geun Yoon-
dc.identifier.doi22552354-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02625-
dc.contributor.localIdA04225-
dc.relation.journalcodeJ01132-
dc.identifier.eissn1791-244X-
dc.identifier.pmid22552354-
dc.identifier.urlhttp://www.spandidos-publications.com/ijmm/30/1/193-
dc.subject.keywordAlzheimer Disease/drug therapy*-
dc.subject.keywordAmyloid beta-Peptides/metabolism*-
dc.subject.keywordAnimals-
dc.subject.keywordApoptosis/drug effects-
dc.subject.keywordCell Survival/drug effects-
dc.subject.keywordChalcone/analogs & derivatives*-
dc.subject.keywordChalcones/pharmacology*-
dc.subject.keywordChalcones/therapeutic use-
dc.subject.keywordChalcones/toxicity-
dc.subject.keywordCognition Disorders/drug therapy*-
dc.subject.keywordLethal Dose 50-
dc.subject.keywordMale-
dc.subject.keywordMaze Learning-
dc.subject.keywordMemory Disorders/drug therapy*-
dc.subject.keywordMice-
dc.subject.keywordMice, Inbred ICR-
dc.subject.keywordNeuroprotective Agents/pharmacology-
dc.subject.keywordNeuroprotective Agents/therapeutic use*-
dc.subject.keywordOxidative Stress/drug effects*-
dc.subject.keywordOximes/pharmacology*-
dc.subject.keywordOximes/therapeutic use-
dc.subject.keywordOximes/toxicity-
dc.subject.keywordPC12 Cells-
dc.subject.keywordRandom Allocation-
dc.subject.keywordRats-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameChoi, Hyo Kyoung-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorChoi, Hyo Kyoung-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPage193-
dc.citation.endPage198-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.30(1) : 193-198, 2012-
dc.identifier.rimsid32801-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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