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Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현기 | - |
dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2014-12-19T16:55:03Z | - |
dc.date.available | 2014-12-19T16:55:03Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90435 | - |
dc.description.abstract | Etoposide-induced gene 24 (Ei24) is a p53 target gene that inhibits growth, induces apoptosis and autophagy, as well as suppresses breast cancer. To evaluate the role of Ei24 in in vivo tumorigenesis, we generated an Ei24-deficient mouse model. Here, we report that, although Ei24 homozygous knockout mice are embryonic lethal, Ei24 heterozygous null mice are attenuated to DMBA/TPA-induced carcinogenesis with regard to the number and size of tumors but not the incidence. Ei24 contains a functional consensus motif, named as an R motif that is highly analogous to amino acids 105-110 of RINCK1, an E3 ligase for protein kinase C (PKC) proteins. We found that Ei24 stabilizes PKCαvia RINCK degradation and competition with RINCK for binding with the C1a domain of PKCα. We also found that Ei24 contributes to PKCα-mediated transactivation of EGFR by promoting PKCα membrane localization and interaction with EGFR. Finally, using Oncomine database we show that Ei24 and EGFR are upregulated in some subsets of human HNSCC. These results suggest that Ei24 is a regulator of the RINCK1-PKCα-EGFR signaling pathway in the development of skin-cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 9,10-Dimethyl-1,2-benzanthracene | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/chemistry | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/deficiency* | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/metabolism | - |
dc.subject.MESH | Binding, Competitive | - |
dc.subject.MESH | Cell Transformation, Neoplastic/pathology* | - |
dc.subject.MESH | Clone Cells | - |
dc.subject.MESH | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/metabolism* | - |
dc.subject.MESH | Cytoprotection | - |
dc.subject.MESH | Enzyme Stability | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratinocytes/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Nuclear Proteins/chemistry | - |
dc.subject.MESH | Nuclear Proteins/deficiency* | - |
dc.subject.MESH | Nuclear Proteins/metabolism | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Proteolysis | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/metabolism | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Skin Neoplasms/enzymology* | - |
dc.subject.MESH | Skin Neoplasms/pathology* | - |
dc.subject.MESH | Transcriptional Activation/genetics | - |
dc.title | Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sushil Devkota | - |
dc.contributor.googleauthor | Young Hoon Sung | - |
dc.contributor.googleauthor | Jung-Min Choi | - |
dc.contributor.googleauthor | Jaehoon Lee | - |
dc.contributor.googleauthor | Na Young Ha | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Jaewhan Song | - |
dc.contributor.googleauthor | Han-Woong Lee | - |
dc.identifier.doi | 22771957 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03822 | - |
dc.relation.journalcode | J01089 | - |
dc.identifier.eissn | 1878-5875 | - |
dc.identifier.pmid | 22771957 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1357272512002336 | - |
dc.subject.keyword | DMBA/TPA skin-carcinogenesis | - |
dc.subject.keyword | EGFR | - |
dc.subject.keyword | Ei24 | - |
dc.subject.keyword | PKCα | - |
dc.subject.keyword | RINCK1 | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.citation.volume | 44 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1887 | - |
dc.citation.endPage | 1896 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Vol.44(11) : 1887-1896, 2012 | - |
dc.identifier.rimsid | 32760 | - |
dc.type.rims | ART | - |
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