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Clinical outcomes and prognostic factors for thiopurine maintenance therapy in patients with intestinal Behcet's disease.

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dc.contributor.author김태일-
dc.contributor.author정윤숙-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.contributor.author김원호-
dc.date.accessioned2014-12-19T16:54:25Z-
dc.date.available2014-12-19T16:54:25Z-
dc.date.issued2012-
dc.identifier.issn1078-0998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90415-
dc.description.abstractBACKGROUND: To date, there have been no studies focusing on the efficacy of thiopurine therapy in intestinal Behcet's disease (BD). We conducted this study to investigate clinical outcomes and predictors of clinical relapse in intestinal BD patients receiving thiopurine maintenance therapy. METHODS: We reviewed the medical records of all patients with intestinal BD who received thiopurine therapy in a single tertiary academic medical center between March 1986 and October 2010. The cumulative probabilities of clinical relapse after remission were calculated using the Kaplan-Meier method. Predictors of clinical relapse were identified by univariate analysis using the log-rank test and by multivariate analysis using Cox proportional hazards regression models. RESULTS: Of a total of 272 patients with intestinal BD, 67 (24.6%) received their first course of thiopurine therapy at our center. Thirty-nine (58.2%) of the 67 patients constantly received thiopurines for maintaining medically or surgically induced remission. The cumulative relapse rates at 1 year, 2 years, 3 years, and 5 years after remission were 5.8%, 28.7%, 43.7%, and 51.7%, respectively. On multivariate analysis, a younger age (<25 years) at diagnosis and a lower hemoglobin level (<11 g/dL) were independent predictive factors for relapse in intestinal BD patients receiving thiopurine maintenance therapy. CONCLUSIONS: Thiopurine therapy showed a relatively good effect for maintenance of remission in intestinal BD patients. However, a younger age at diagnosis and a lower hemoglobin level were associated with a poor response to thiopurines, necessitating early adoption of effective alternative therapeutic options in these risk groups-
dc.description.statementOfResponsibilityopen-
dc.format.extent750~757-
dc.relation.isPartOfINFLAMMATORY BOWEL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge of Onset-
dc.subject.MESHAzathioprine/adverse effects-
dc.subject.MESHAzathioprine/therapeutic use*-
dc.subject.MESHBehcet Syndrome/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHemoglobins/analysis-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/adverse effects-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleClinical outcomes and prognostic factors for thiopurine maintenance therapy in patients with intestinal Behcet's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYoon Suk Jung-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi21618352-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01079-
dc.contributor.localIdA03680-
dc.contributor.localIdA04404-
dc.contributor.localIdA00774-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ01060-
dc.identifier.eissn1536-4844-
dc.identifier.pmid21618352-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00054725-201204000-00018&LSLINK=80&D=ovft-
dc.subject.keywordhiopurine-
dc.subject.keywordazathioprine-
dc.subject.keywordintestinal Behcet’s disease-
dc.subject.keywordremission-
dc.subject.keywordrelapse-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameJung, Yoon Suk-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorJung, Yoon Suk-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume18-
dc.citation.number4-
dc.citation.startPage750-
dc.citation.endPage757-
dc.identifier.bibliographicCitationINFLAMMATORY BOWEL DISEASES, Vol.18(4) : 750-757, 2012-
dc.identifier.rimsid34203-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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