Cited 14 times in
Changes in serum levels of cartilage oligomeric matrix protein after estrogen and alendronate therapy in postmenopausal women
DC Field | Value | Language |
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dc.contributor.author | 서석교 | - |
dc.contributor.author | 양효인 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 임경진 | - |
dc.contributor.author | 전영은 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2014-12-19T16:51:31Z | - |
dc.date.available | 2014-12-19T16:51:31Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0378-7346 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90327 | - |
dc.description.abstract | BACKGROUND: Cartilage oligomeric matrix protein (COMP) is a biomarker for joint destruction and its serum levels are used for assessing therapeutic efficacy. This study aims to compare changes in serum COMP levels in postmenopausal women with osteopenia/osteoporosis receiving estrogen and alendronate. METHODS: A total of 62 postmenopausal women diagnosed with osteopenia or osteoporosis were treated with either estrogen (17β-estradiol 1 mg, n = 30) or bisphosphonate (alendronate 5 mg, n = 32) for 6 months. The controls were healthy postmenopausal women (n = 30). Serum COMP and osteocalcin levels were measured at baseline and after 6 months of treatment. RESULTS: Estrogen decreased levels of COMP at 6 months compared to baseline levels (–8.35 ± 19.38%), whereas the bisphosphonate and control groups resulted in no significant changes (–5.50 ± 18.69 and –1.49 ± 25.34%, respectively). Concentrations of osteocalcin decreased significantly in both treatment groups (estrogen –25.60 ± 24.42% and alendronate –13.76 ± 23.89%, respectively). There was a significant positive correlation between changes after 6 months in COMP and osteocalcin (R = 0.48, p = 0.002). CONCLUSIONS: Postmenopausal women treated with estrogen showed significantly decreased levels of COMP after 6 months. Estrogen might provide a further treatment modality in the prevention of joint destruction. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alendronate/therapeutic use* | - |
dc.subject.MESH | Androstenes/therapeutic use | - |
dc.subject.MESH | Bone Density | - |
dc.subject.MESH | Bone Density Conservation Agents* | - |
dc.subject.MESH | Bone Diseases, Metabolic/drug therapy | - |
dc.subject.MESH | Cartilage/drug effects | - |
dc.subject.MESH | Cartilage/physiopathology | - |
dc.subject.MESH | Cartilage Oligomeric Matrix Protein | - |
dc.subject.MESH | Estradiol/therapeutic use* | - |
dc.subject.MESH | Extracellular Matrix Proteins/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycoproteins/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrilin Proteins | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mineralocorticoid Receptor Antagonists | - |
dc.subject.MESH | Osteoarthritis/prevention & control | - |
dc.subject.MESH | Osteocalcin/blood | - |
dc.subject.MESH | Osteoporosis, Postmenopausal/drug therapy* | - |
dc.subject.MESH | Postmenopause/physiology* | - |
dc.title | Changes in serum levels of cartilage oligomeric matrix protein after estrogen and alendronate therapy in postmenopausal women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Hyo In Yang | - |
dc.contributor.googleauthor | Kyung Jin Lim | - |
dc.contributor.googleauthor | Young Eun Jeon | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 10.1159/000339934 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02329 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03356 | - |
dc.contributor.localId | A03533 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J00955 | - |
dc.identifier.eissn | 1423-002X | - |
dc.identifier.pmid | 22964967 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/339934 | - |
dc.subject.keyword | Cartilage oligomeric matrix protein | - |
dc.subject.keyword | Osteoarthritis | - |
dc.subject.keyword | Estrogen | - |
dc.subject.keyword | Alendronate | - |
dc.subject.keyword | Menopause | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yang, Hyo In | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Lim, Kyung Jin | - |
dc.contributor.alternativeName | Jeon, Young Eun | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lim, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Jeon, Young Eun | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.citation.volume | 74 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 150 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC AND OBSTETRIC INVESTIGATION, Vol.74(2) : 143-150, 2012 | - |
dc.identifier.rimsid | 34145 | - |
dc.type.rims | ART | - |
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