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Examining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans.

DC FieldValueLanguage
dc.contributor.author지선하-
dc.date.accessioned2014-12-19T16:50:58Z-
dc.date.available2014-12-19T16:50:58Z-
dc.date.issued2012-
dc.identifier.issn0741-0395-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90310-
dc.description.abstractIn a recent genome-wide association study (GWAS) from an international consortium, evidence of linkage and association in chr8q24 was much stronger among nonsyndromic cleft lip/palate (CL/P) case-parent trios of European ancestry than among trios of Asian ancestry. We examined marker information content and haplotype diversity across 13 recruitment sites (from Europe, United States, and Asia) separately, and conducted principal components analysis (PCA) on parents. As expected, PCA revealed large genetic distances between Europeans and Asians, and a north-south cline from Korea to Singapore in Asia, with Filipino parents forming a somewhat distinct Southeast Asian cluster. Hierarchical clustering of SNP heterozygosity revealed two major clades consistent with PCA results. All genotyped SNPs giving P < 10(-6) in the allelic transmission disequilibrium test (TDT) showed higher heterozygosity in Europeans than Asians. On average, European ancestry parents had higher haplotype diversity than Asians. Imputing additional variants across chr8q24 increased the strength of statistical evidence among Europeans and also revealed a significant signal among Asians (although it did not reach genome-wide significance). Tests for SNP-population interaction were negative, indicating the lack of strong signal for 8q24 in families of Asian ancestry was not due to any distinct genetic effect, but could simply reflect low power due to lower allele frequencies in Asians.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfGENETIC EPIDEMIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHChromosomes, Human, Pair 8*-
dc.subject.MESHCleft Lip/complications-
dc.subject.MESHCleft Lip/ethnology-
dc.subject.MESHCleft Lip/genetics*-
dc.subject.MESHCleft Palate/complications-
dc.subject.MESHCleft Palate/ethnology-
dc.subject.MESHCleft Palate/genetics*-
dc.subject.MESHCluster Analysis-
dc.subject.MESHEuropean Continental Ancestry Group-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenome-
dc.subject.MESHGenotype-
dc.subject.MESHHaplotypes-
dc.subject.MESHHeterozygote-
dc.subject.MESHHumans-
dc.subject.MESHLinkage Disequilibrium-
dc.subject.MESHModels, Genetic-
dc.subject.MESHPrincipal Component Analysis-
dc.titleExamining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans.-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorTanda Murray-
dc.contributor.googleauthorMargaret A. Taub-
dc.contributor.googleauthorIngo Ruczinski-
dc.contributor.googleauthorAlan F. Scott-
dc.contributor.googleauthorJacqueline B. Hetmanski-
dc.contributor.googleauthorHolger Schwender-
dc.contributor.googleauthorPoorav Patel-
dc.contributor.googleauthorTian Xiao Zhang-
dc.contributor.googleauthorRonald G. Munger-
dc.contributor.googleauthorAllen J. Wilcox-
dc.contributor.googleauthorXiaoqian Ye-
dc.contributor.googleauthorHong Wang-
dc.contributor.googleauthorTao Wu-
dc.contributor.googleauthorYah Huei Wu-Chou-
dc.contributor.googleauthorBing Shi-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorSamuel Chong-
dc.contributor.googleauthorVincent Yeow-
dc.contributor.googleauthorJeffrey C. Murray-
dc.contributor.googleauthorMary L. Marazita-
dc.contributor.googleauthorTerri H. Beaty-
dc.identifier.doi22508319-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00931-
dc.identifier.eissn1098-2272-
dc.identifier.pmid22508319-
dc.subject.keywordcleft lip with/without cleft palate-
dc.subject.keyword8q24-
dc.subject.keywordgenome wide association-
dc.subject.keywordimputation-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume36-
dc.citation.number4-
dc.citation.startPage392-
dc.citation.endPage399-
dc.identifier.bibliographicCitationGENETIC EPIDEMIOLOGY, Vol.36(4) : 392-399, 2012-
dc.identifier.rimsid34135-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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