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Prediction of early response to uterine arterial embolisation of adenomyosis: value of T2 signal intensity ratio of adenomyosis.

 Dae Chul Jung  ;  Man Deuk Kim  ;  Young Taik Oh  ;  Jong Yun Won  ;  Do Yun Lee 
 EUROPEAN RADIOLOGY, Vol.22(9) : 2044-2049, 2012 
Journal Title
Issue Date
Adenomyosis/pathology* ; Adenomyosis/therapy* ; Adult ; Early Diagnosis ; Female ; Hemostatics/therapeutic use ; Humans ; Middle Aged ; Polyvinyl Alcohol/therapeutic use* ; Prognosis ; Treatment Outcome ; Uterine Artery Embolization/methods*
Uterine arterial embolisation ; Adenomyosis ; Magnetic resonance ; Signal intensity ratio ; Prediction
OBJECTIVES: To identify imaging predictors for complete necrosis after uterine artery embolisation (UAE) via quantitative measurement of the signal intensity obtained from magnetic resonance imaging (MRI) of a patient with adenomyosis. METHODS: The MRIs of 119 patients with uterine adenomyosis, who underwent UAE, were retrospectively evaluated. Each lesion was classified based on its location and morphology on MRI. Thickness and signal intensity were measured in each adenomyosis and in the rectus muscle on the T2-weighted sagittal plane, and the T2-weighted signal intensity ratio (T2SR) was calculated. MR parameters were then compared in patients showing complete response that achieved complete necrosis and incomplete response after UAE via univariate and multivariate analysis. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of the predictor using MR parameters for differentiating the complete from the incomplete response. RESULTS: The complete necrosis rate was 66.4 % (79/119) after UAE for adenomyosis. Univariate and multivariate analysis results indicated that T2SR was associated significantly with complete necrosis (P = 0.012). Symptomatic adenomyosis with T2SR above 0.475 was associated with complete necrosis after UAE (sensitivity = 57.0, specificity = 70.0, area under the ROC curve [AUC] = 0.643). CONCLUSION: T2SR of adenomyosis on pre-procedural MRI can be utilised as a predictor for early therapeutic response of UAE in adenomyosis.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Man Deuk(김만득) ORCID logo https://orcid.org/0000-0002-3575-5847
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Lee, Do Yun(이도연)
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
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