Cited 0 times in
Mitochondria DNA polymorphisms are associated with susceptibility to endometriosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김혜연 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 양효인 | - |
dc.contributor.author | 이경은 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 이영목 | - |
dc.contributor.author | 임경진 | - |
dc.contributor.author | 전영은 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2014-12-19T16:46:03Z | - |
dc.date.available | 2014-12-19T16:46:03Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1044-5498 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90155 | - |
dc.description.abstract | Because energy production involves oxidative phosphorylation, mitochondria are major sources of reactive oxygen species in the cell. Recent findings indicate that mitochondrial DNA (mtDNA) variants may play a role in the etiology of certain autoimmune and chronic inflammatory diseases. The aim of this study was to investigate the possible association between mtDNA polymorphisms and susceptibility to endometriosis. This study included 198 patients with histologically confirmed endometriosis and 167 patients without endometriosis as controls. Common variants of mtDNA at nt10398 (A/G transition), nt13708 (G/A transition), and nt16189 (T/C transition) were detected using polymerase chain reaction. An association study was performed with a chi-square test and logistic regression analysis. The prevalence of the mtDNA nt16189 variant was higher in patients with endometriosis (46.0%, 91 of 198) than in controls (34.7%, 58 of 167) (p=0.030) with odds ratio (OR) of 1.98 (95% confidence interval [CI]: 1.04-3.78). A combination of the 10398 and 16189 variants was also associated with increased risk for endometriosis (OR=1.90, 95% CI: 1.13-3.18, p=0.015). These associations remained significant even after adjusting for age and body mass index. Our data strongly suggest that the mtDNA 16189 variants and the combination of mtDNA 16189 and 10398 variants increase susceptibility to endometriosis | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DNA AND CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | DNA, Mitochondrial/genetics* | - |
dc.subject.MESH | Endometriosis/genetics* | - |
dc.subject.MESH | Endometriosis/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.title | Mitochondria DNA polymorphisms are associated with susceptibility to endometriosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young-Mock Lee | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Hyo In Yang | - |
dc.contributor.googleauthor | Young Eun Jeon | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | KyungJin Lim | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 21848429 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02650 | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02329 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A02955 | - |
dc.contributor.localId | A03356 | - |
dc.contributor.localId | A03533 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J00746 | - |
dc.identifier.eissn | 1557-7430 | - |
dc.identifier.pmid | 21848429 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/dna.2011.1279 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | DNA, Mitochondrial/genetics* | - |
dc.subject.keyword | Endometriosis/genetics* | - |
dc.subject.keyword | Endometriosis/pathology | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Genetic Predisposition to Disease* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Neoplasm Staging | - |
dc.subject.keyword | Oxidative Stress | - |
dc.subject.keyword | Polymorphism, Single Nucleotide* | - |
dc.subject.keyword | Reactive Oxygen Species/metabolism | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yang, Hyo In | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Lee, Young Mock | - |
dc.contributor.alternativeName | Lim, Kyung Jin | - |
dc.contributor.alternativeName | Jeon, Young Eun | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Young Mock | - |
dc.contributor.affiliatedAuthor | Lim, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Jeon, Young Eun | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.citation.volume | 31 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 317 | - |
dc.citation.endPage | 322 | - |
dc.identifier.bibliographicCitation | DNA AND CELL BIOLOGY, Vol.31(3) : 317-322, 2012 | - |
dc.identifier.rimsid | 32395 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.