Cited 87 times in
Liver stiffness measurement using acoustic radiation force impulse (ARFI) elastography and effect of necroinflammation
DC Field | Value | Language |
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dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김승업 | - |
dc.date.accessioned | 2014-12-19T16:45:42Z | - |
dc.date.available | 2014-12-19T16:45:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90144 | - |
dc.description.abstract | BACKGROUND: Acoustic radiation force impulse (ARFI) elastography can be used to assess the degree of liver fibrosis. AIM: We evaluated the performance of ARFI elastography in assessment of liver fibrosis and compared it with the performance of aspartate aminotransferase-to-platelet ratio index (APRI) and transient elastography with Fibroscan (FS). METHODS: We prospectively analyzed 250 consecutive patients who underwent liver biopsy and ARFI from June 2010 to May 2011. Reliable FS values were obtained for 97 (38.8%) patients. RESULTS: The mean age of patients (147 male and 103 female) was 46.6 years. Liver stiffness values obtained by use of ARFI elastography significantly correlated with histological fibrosis stage (R = 0.575, P < 0.001). Area under the receiver operating characteristics curves (AUROCs) of ARFI elastography for predicting significant fibrosis (≥F2) and cirrhosis (F4) was 0.74 (95% confidence interval [CI], 0.64-0.86, P = 0.001) and 0.79 (95% CI, 0.67-0.91, P = 0.001), respectively, and those for APRI were 0.69 (95% CI, 0.58-0.79, P = 0.001) and 0.76 (95% CI, 0.64-0.85, P < 0.001), respectively. The optimum cutoff values for ARFI elastography were 1.13 m/s for ≥F2 and 1.98 m/s for F4; these decreased to 1.09 m/s for ≥F2 and 1.81 m/s for F4 when 131 patients with normal alanine aminotransferase (ALT) were selected. In the sub-group of 97 patients with reliable FS values, the performance in predicting ≥F2 or F4 was equivalent between ARFI elastography and FS. CONCLUSIONS: ARFI elastography is a reliable surrogate marker of liver fibrosis, if its relationship with biochemical markers, for example ALT level, is taken into account. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aspartate Aminotransferases/analysis | - |
dc.subject.MESH | Aspartate Aminotransferases/metabolism* | - |
dc.subject.MESH | Biopsy, Needle | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Elasticity Imaging Techniques/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hepatitis/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Cirrhosis/diagnosis | - |
dc.subject.MESH | Liver Cirrhosis/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Necrosis/pathology | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Liver stiffness measurement using acoustic radiation force impulse (ARFI) elastography and effect of necroinflammation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ki Tae Yoon | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | Mong Cho | - |
dc.contributor.googleauthor | Jun Woo Lee | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.identifier.doi | 10.1007/s10620-012-2044-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 22302243 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10620-012-2044-4 | - |
dc.subject.keyword | Acoustic radiation force impulse elastography | - |
dc.subject.keyword | Aspartate aminotransferase-to-platelet ratio index | - |
dc.subject.keyword | Chronic liver disease | - |
dc.subject.keyword | Fibroscan | - |
dc.subject.keyword | Fibrosis | - |
dc.subject.keyword | Liver stiffness | - |
dc.subject.keyword | Transient elastography | - |
dc.subject.keyword | Cirrhosis | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lim, Sun Min | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lim, Sun Min | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1682 | - |
dc.citation.endPage | 1691 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.57(6) : 1682-1691, 2012 | - |
dc.identifier.rimsid | 32388 | - |
dc.type.rims | ART | - |
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