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Prediction of esophageal variceal bleeding in B-viral liver cirrhosis using the P2/MS noninvasive index based on complete blood counts.

DC FieldValueLanguage
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author전재윤-
dc.contributor.author조중현-
dc.contributor.author김도영-
dc.contributor.author한광협-
dc.contributor.author김범경-
dc.contributor.author한민석-
dc.contributor.author김자경-
dc.contributor.author박준용-
dc.date.accessioned2014-12-19T16:45:25Z-
dc.date.available2014-12-19T16:45:25Z-
dc.date.issued2012-
dc.identifier.issn0012-2823-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90135-
dc.description.abstractBACKGROUND/AIM: Periodic endoscopy for esophageal varices (EVs) and prophylactic treatment of high-risk EVs, i.e., medium/large EVs, small EVs with the red-color sign or decompensation, are recommended in cirrhotic patients. We assessed the cumulative risks for future EV bleeding using the following simple P2/MS index: (platelet count)2/[monocyte fraction (%) × segmented neutrophil fraction (%)]. METHODS: We enrolled 475 consecutive B-viral cirrhosis patients for 4 years, none of whom experienced EV bleeding. All underwent laboratory work-ups, endoscopy and ultrasonography. Those with EV bleeding took a nonselective β-blocker as prophylaxis. The major endpoint was the first occurrence of EV bleeding, analyzed using the Kaplan-Meier and Cox regression methods. RESULTS: Among patients with EV bleeding (n = 131), 25 experienced their first EV bleeding during follow-up. To differentiate the risk for EV bleeding, we divided them into two subgroups according to their P2/MS value (subgroup 1: P2/MS ≥9 and subgroup 2: P2/MS <9). The risk was significantly higher in subgroup 2 (p = 0.029). From multivariate analysis, a lower P2/MS (p = 0.040) remained a significant predictor for EV bleeding along with large varix size (p = 0.015), red-color sign (p = 0.041) and Child-Pugh classification B/C (p = 0.001). In subgroup 1, the risk for EV bleeding was similar to that of patients with low-risk EVs (p = 0.164). CONCLUSIONS: The P2/MS is a reliable predictor for the risk of EV bleeding among patients with EV bleeding. According to risk stratification, different prophylactic treatments should be considered for the subgroup with a P2/MS <9.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfDigestion-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrediction of esophageal variceal bleeding in B-viral liver cirrhosis using the P2/MS noninvasive index based on complete blood counts.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKim B.K.-
dc.contributor.googleauthorAhn S.H.-
dc.contributor.googleauthorHan K.-H.-
dc.contributor.googleauthorPark J.Y.-
dc.contributor.googleauthorHan M.S.-
dc.contributor.googleauthorJo J.H.-
dc.contributor.googleauthorKim J.K.-
dc.contributor.googleauthorLee K.S.-
dc.contributor.googleauthorChon C.Y.-
dc.contributor.googleauthorKim D.Y.-
dc.identifier.doi10.1159/000341507-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03912-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA04281-
dc.contributor.localIdA00852-
dc.contributor.localIdA01675-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00734-
dc.identifier.urlhttp://www.karger.com/Article/FullText/341507-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameJo, Jung Hyun-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameHan, Min Seok-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorJo, Jung Hyun-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorHan, Min Seok-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume86-
dc.citation.number3-
dc.citation.startPage264-
dc.citation.endPage272-
dc.identifier.bibliographicCitationDigestion, Vol.86(3) : 264-272, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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