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Prediction of esophageal variceal bleeding in B-viral liver cirrhosis using the P2/MS noninvasive index based on complete blood counts.
DC Field | Value | Language |
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dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 조중현 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 한민석 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 박준용 | - |
dc.date.accessioned | 2014-12-19T16:45:25Z | - |
dc.date.available | 2014-12-19T16:45:25Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0012-2823 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90135 | - |
dc.description.abstract | BACKGROUND/AIM: Periodic endoscopy for esophageal varices (EVs) and prophylactic treatment of high-risk EVs, i.e., medium/large EVs, small EVs with the red-color sign or decompensation, are recommended in cirrhotic patients. We assessed the cumulative risks for future EV bleeding using the following simple P2/MS index: (platelet count)2/[monocyte fraction (%) × segmented neutrophil fraction (%)]. METHODS: We enrolled 475 consecutive B-viral cirrhosis patients for 4 years, none of whom experienced EV bleeding. All underwent laboratory work-ups, endoscopy and ultrasonography. Those with EV bleeding took a nonselective β-blocker as prophylaxis. The major endpoint was the first occurrence of EV bleeding, analyzed using the Kaplan-Meier and Cox regression methods. RESULTS: Among patients with EV bleeding (n = 131), 25 experienced their first EV bleeding during follow-up. To differentiate the risk for EV bleeding, we divided them into two subgroups according to their P2/MS value (subgroup 1: P2/MS ≥9 and subgroup 2: P2/MS <9). The risk was significantly higher in subgroup 2 (p = 0.029). From multivariate analysis, a lower P2/MS (p = 0.040) remained a significant predictor for EV bleeding along with large varix size (p = 0.015), red-color sign (p = 0.041) and Child-Pugh classification B/C (p = 0.001). In subgroup 1, the risk for EV bleeding was similar to that of patients with low-risk EVs (p = 0.164). CONCLUSIONS: The P2/MS is a reliable predictor for the risk of EV bleeding among patients with EV bleeding. According to risk stratification, different prophylactic treatments should be considered for the subgroup with a P2/MS <9. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DIGESTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Blood Cell Count | - |
dc.subject.MESH | Endoscopy, Gastrointestinal | - |
dc.subject.MESH | Esophageal and Gastric Varices/diagnosis* | - |
dc.subject.MESH | Esophageal and Gastric Varices/epidemiology | - |
dc.subject.MESH | Esophageal and Gastric Varices/etiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/blood | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/diagnosis | - |
dc.subject.MESH | Gastrointestinal Hemorrhage/etiology* | - |
dc.subject.MESH | Hepatitis B, Chronic/blood | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Hepatitis B, Chronic/diagnosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Liver Cirrhosis/blood | - |
dc.subject.MESH | Liver Cirrhosis/complications* | - |
dc.subject.MESH | Liver Cirrhosis/diagnosis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Prediction of esophageal variceal bleeding in B-viral liver cirrhosis using the P2/MS noninvasive index based on complete blood counts. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Kim B.K. | - |
dc.contributor.googleauthor | Ahn S.H. | - |
dc.contributor.googleauthor | Han K.-H. | - |
dc.contributor.googleauthor | Park J.Y. | - |
dc.contributor.googleauthor | Han M.S. | - |
dc.contributor.googleauthor | Jo J.H. | - |
dc.contributor.googleauthor | Kim J.K. | - |
dc.contributor.googleauthor | Lee K.S. | - |
dc.contributor.googleauthor | Chon C.Y. | - |
dc.contributor.googleauthor | Kim D.Y. | - |
dc.identifier.doi | 22986832 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A03912 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A04281 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J00734 | - |
dc.identifier.eissn | 1421-9867 | - |
dc.identifier.pmid | 22986832 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/341507 | - |
dc.subject.keyword | Liver cirrhosis | - |
dc.subject.keyword | Esophageal variceal bleeding | - |
dc.subject.keyword | Prediction | - |
dc.subject.keyword | Endoscopy | - |
dc.subject.keyword | P2/MS | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Jo, Jung Hyun | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.alternativeName | Han, Min Seok | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Jo, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | Han, Min Seok | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 86 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 272 | - |
dc.identifier.bibliographicCitation | DIGESTION, Vol.86(3) : 264-272, 2012 | - |
dc.identifier.rimsid | 32381 | - |
dc.type.rims | ART | - |
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