Cited 112 times in
Differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2014-12-19T16:44:52Z | - |
dc.date.available | 2014-12-19T16:44:52Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90117 | - |
dc.description.abstract | OBJECTIVE: We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors. RESEARCH DESIGN AND METHODS: We identified 23,643 consecutive individuals without known CAD undergoing coronary computed tomography angiography. A total of 3,370 DM individuals were propensity matched in a 1-to-2 fashion to 6,740 unique non-DM individuals. CAD was defined as none, nonobstructive (1-49% stenosis), or obstructive (≥ 50% stenosis). All-cause mortality was assessed by risk-adjusted Cox proportional hazards models. RESULTS: At a 2.2-year follow-up, 108 (3.2%) and 115 (1.7%) deaths occurred among DM and non-DM individuals, respectively. Compared with non-DM individuals, DM individuals possessed higher rates of obstructive CAD (37 vs. 27%) and lower rates of having normal arteries (28 vs. 36%) (P < 0.0001). CAD extent was higher for DM versus non-DM individuals for obstructive one-vessel disease (19 vs. 14%), two-vessel disease (9 vs. 7%), and three-vessel disease (9 vs. 5%) (P < 0.0001 for comparison), with higher per-segment stenosis in the proximal and mid-segments of every coronary artery (P < 0.001 for all). Compared with non-DM individuals with no CAD, risk of mortality for DM individuals was higher for those with no CAD (hazard ratio 3.63 [95% CI 1.67-7.91]; P = 0.001), nonobstructive CAD (5.25 [2.56-10.8]; P < 0.001), one-vessel disease (6.39 [2.98-13.7]; P < 0.0001), two-vessel disease (12.33 [5.622-27.1]; P < 0.0001), and three-vessel disease (13.25 [6.15-28.6]; P < 0.0001). CONCLUSIONS: Compared with matched non-DM individuals, DM individuals possess higher prevalence, extent, and severity of CAD. At comparable levels of CAD, DM individuals experience higher risk of mortality compared with non-DM individuals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | DIABETES CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Coronary Angiography/methods* | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology* | - |
dc.subject.MESH | Coronary Artery Disease/pathology* | - |
dc.subject.MESH | Diabetes Mellitus/physiopathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Prognosis | - |
dc.title | Differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Rana, Jamal S | - |
dc.contributor.googleauthor | Dunning, Allison | - |
dc.contributor.googleauthor | Achenbach, Stephan | - |
dc.contributor.googleauthor | Al-Mallah, Mouaz | - |
dc.contributor.googleauthor | Budoff, Matthew J | - |
dc.identifier.doi | 10.2337/dc11-2403 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00721 | - |
dc.identifier.eissn | 1935-5548 | - |
dc.identifier.pmid | 22699296 | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Coronary Angiography/methods* | - |
dc.subject.keyword | Coronary Artery Disease/epidemiology* | - |
dc.subject.keyword | Coronary Artery Disease/pathology* | - |
dc.subject.keyword | Diabetes Mellitus/physiopathology* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Prevalence | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1787 | - |
dc.citation.endPage | 1794 | - |
dc.identifier.bibliographicCitation | DIABETES CARE, Vol.35(8) : 1787-1794, 2012 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.