Cited 133 times in
The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2014-12-19T16:41:45Z | - |
dc.date.available | 2014-12-19T16:41:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90016 | - |
dc.description.abstract | OBJECTIVE: To determine whether circulating metabolic intermediates are associated with inflammation, oxidative stress and arterial stiffness in men with newly diagnosed type 2 diabetes and investigate the circulating metabolic intermediates that may predict the risk of developing diabetes. RESEARCH DESIGN AND METHODS: Men with newly diagnosed type 2 diabetes (n = 26) and age- and body mass index-matched nondiabetic men (n = 27) were included. We measured inflammatory and oxidative markers and arterial stiffness by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analysed with ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometry. RESULTS: Diabetic men showed higher circulating levels of glucose, triglyceride, oxidized low-density lipoprotein (LDL), high-sensitivity C-reactive protein, interleukin (IL)-6, tumour necrosis factor-alpha (TNF-α), homeostasis model assessment-insulin resistance, urinary 8-epi-prostaglandin F(2α) (8-epi-PGF(2α)) and ba-PWV than nondiabetic men. In plasma, 19 metabolites including three amino acids, eight acylcarnitines, six lysophosphatidylcholines (lysoPCs), and two lysophosphatidylethanolamines (lysoPEs; C18:2 and C22:6) significantly increased in diabetes men, whereas serine and lysoPE (C18:1) decreased. Decanoyl carnitine, lysoPCs (C14:0, C16:1, C18:1 and C22:6) and lysoPE (C18:1) with variable importance in the projection values >1·0 were major plasma metabolites that distinguished nondiabetic and diabetic men. Decanoyl carnitine positively correlated with oxidized LDL, 8-epi-PGF(2α), IL-6, TNF-α and ba-PWV. ba-PWV correlated positively with lysoPCs C14:0 and C16:1, and negatively with lysoPE C18:1. 8-epi-PGF(2α) correlated positively with lipoprotein-associated phospholipase A(2), ba-PWV and lysoPCs (C14:0 and C16:1). The receiver operating characteristic curve estimation suggested that decanoyl carnitine and lysoPC (C14:0) are the best metabolites for predicting the risk of developing diabetes. CONCLUSIONS: Circulating lipid-related intermediate metabolites can be closely associated with inflammation, oxidative stress and arterial stiffness in early diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/blood | - |
dc.subject.MESH | Inflammation/metabolism* | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Lipid Metabolism* | - |
dc.subject.MESH | Lipid Peroxides/blood | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Lipids/chemistry | - |
dc.subject.MESH | Lipoproteins, LDL/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mass Spectrometry/methods | - |
dc.subject.MESH | Metabolome | - |
dc.subject.MESH | Metabolomics/methods | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Oxidative Stress* | - |
dc.subject.MESH | Phospholipids/blood | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood | - |
dc.subject.MESH | Vascular Stiffness* | - |
dc.title | The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chang Young Ha | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Yong-Han Paik | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1111/j.1365-2265.2011.04244.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J00571 | - |
dc.identifier.eissn | 1365-2265 | - |
dc.identifier.pmid | 21958081 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04244.x/abstract | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.citation.volume | 76 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 674 | - |
dc.citation.endPage | 682 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, Vol.76(5) : 674-682, 2012 | - |
dc.identifier.rimsid | 32309 | - |
dc.type.rims | ART | - |
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