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High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma.

DC FieldValueLanguage
dc.contributor.author김세훈-
dc.contributor.author김주항-
dc.contributor.author박무석-
dc.contributor.author심효섭-
dc.contributor.author조병철-
dc.date.accessioned2014-12-19T16:41:35Z-
dc.date.available2014-12-19T16:41:35Z-
dc.date.issued2012-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90011-
dc.description.abstractPURPOSE: This study aimed to search for predictors of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) efficacy in previously treated patients with advanced squamous cell lung carcinoma in which EGFR mutations are very rare. EXPERIMENTAL DESIGN: EGFR gene copy numbers were assessed by FISH and evaluated as predictors of EGFR-TKI efficacy in 71 patients with advanced squamous cell lung cancer who received gefitinib or erlotinib as a second-line or higher therapy. The tumors were classified into EGFR/FISH-positive (high polysomy/gene amplification) and EGFR/FISH-negative (other) groups. RESULTS: EGFR/FISH was positive in 19 (26.7%) patients. Only EGFR/FISH positive status was correlated with the EGFR-TKIs response (EGFR/FISH(+) vs. EGFR/FISH(-), 26.3% vs. 2.0%; P = 0.005). In a multivariate analysis, the risk of progression was lower in EGFR/FISH-positive patients (HR of EGFR/FISH(+) vs. EGFR/FISH(-), 0.57; P = 0.057) or patients experiencing grade 2 or more rash (HR for rash grade 2 or more vs. less than 2, 0.54; P = 0.042), compared with EGFR/FISH-negative patients or those experiencing grade of less than 2 rash, respectively. When the combined criteria of EGFR/FISH and skin rash severity were analyzed, EGFR/FISH-negative patients with grade less than 2 rash had poorer clinical outcomes than patients with positive EGFR/FISH or grade 2 or more rash, apparent as a lower response rate (0.0% vs. 21.4%; P = 0.003) and a shorter median progression-free survival (1.13 months vs. 3.90 months; P = 0.0002). CONCLUSIONS: EGFR/FISH and skin rash severity may be used to identify which patients are likely to gain a benefit from EGFR-TKIs in this population.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell/drug therapy-
dc.subject.MESHCarcinoma, Squamous Cell/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/mortality-
dc.subject.MESHExanthema/complications*-
dc.subject.MESHFemale-
dc.subject.MESHGene Dosage*-
dc.subject.MESHGenes, erbB-1*-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/drug therapy-
dc.subject.MESHLung Neoplasms/genetics*-
dc.subject.MESHLung Neoplasms/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProtein Kinase Inhibitors/therapeutic use*-
dc.subject.MESHReceptor, Epidermal Growth Factor/antagonists & inhibitors*-
dc.subject.MESHRetreatment-
dc.titleHigh EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYoungjoo Lee-
dc.contributor.googleauthorHyo Sup Shim-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorJoo-Hang Kim-
dc.contributor.googleauthorSang-Jun Ha-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi22271877-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00610-
dc.contributor.localIdA00945-
dc.contributor.localIdA01457-
dc.contributor.localIdA02219-
dc.contributor.localIdA03822-
dc.relation.journalcodeJ00564-
dc.identifier.pmid22271877-
dc.subject.keywordAged-
dc.subject.keywordCarcinoma, Squamous Cell/drug therapy-
dc.subject.keywordCarcinoma, Squamous Cell/genetics*-
dc.subject.keywordCarcinoma, Squamous Cell/mortality-
dc.subject.keywordExanthema/complications*-
dc.subject.keywordFemale-
dc.subject.keywordGene Dosage*-
dc.subject.keywordGenes, erbB-1*-
dc.subject.keywordHumans-
dc.subject.keywordLung Neoplasms/drug therapy-
dc.subject.keywordLung Neoplasms/genetics*-
dc.subject.keywordLung Neoplasms/mortality-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordProtein Kinase Inhibitors/therapeutic use*-
dc.subject.keywordReceptor, Epidermal Growth Factor/antagonists & inhibitors*-
dc.subject.keywordRetreatment-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.citation.volume18-
dc.citation.number6-
dc.citation.startPage1760-
dc.citation.endPage1768-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.18(6) : 1760-1768, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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