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Red blood cell distribution width predicts early mortality in patients with acute dyspnea.

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dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author원호연-
dc.contributor.author윤종찬-
dc.contributor.author장양수-
dc.contributor.author김수영-
dc.date.accessioned2014-12-19T16:40:38Z-
dc.date.available2014-12-19T16:40:38Z-
dc.date.issued2012-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89980-
dc.description.abstractBACKGROUND: Red blood cell distribution width (RDW) has been shown to predict clinical outcomes in cardiovascular diseases. We studied whether RDW is useful to predict early mortality in patients with acute dyspnea at an emergency department (ED). METHODS: We retrospectively analyzed 907 patients with acute dyspnea who visited the ED from January 2009 to May 2009. Primary outcome was 30-day mortality. RESULTS: Acute decompensated heart failure (29.9%) was the most common adjudicated discharge diagnosis followed by cancer (14.8%) and pneumonia (12.5%). There was a stepwise increase of 30-day mortality risk from lowest (RDW<12.9%) to highest (RDW>14.3%) RDW tertiles (1.4% vs. 8.3% vs. 18.3%; log-rank P<0.001). In multivariate Cox hazard analysis, RDW was an independent predictor of 30-day mortality after adjusting for other risk factors (HR 1.23; 95% CI 1.11-1.36; P<0.001). Adding RDW to conventional clinical predictors significantly improved prediction for 30-day mortality as measured by the area under the ROC curve (AUC, from 0.873 to 0.885; P=0.023) and the net reclassification improvement (NRI=14.1%; P<0.001)/integrated discrimination improvement (IDI=0.038; P=0.006). CONCLUSIONS: Our findings suggest that RDW measured at ED is an independent and additive predictor of early mortality in patients with acute dyspnea.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDyspnea/blood*-
dc.subject.MESHDyspnea/mortality*-
dc.subject.MESHErythrocyte Indices*-
dc.subject.MESHFemale-
dc.subject.MESHHeart Failure/mortality-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms/diagnosis-
dc.subject.MESHPneumonia/diagnosis-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.titleRed blood cell distribution width predicts early mortality in patients with acute dyspnea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSoo-Young Kim-
dc.contributor.googleauthorHoyoun Won-
dc.contributor.googleauthorJong Chan Youn-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi22406179-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA02448-
dc.contributor.localIdA02600-
dc.contributor.localIdA03448-
dc.contributor.localIdA02395-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid22406179-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009898112001064-
dc.subject.keywordDyspnea-
dc.subject.keywordMortality-
dc.subject.keywordRed blood cell distribution width-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.alternativeNameWon, Ho Youn-
dc.contributor.alternativeNameYoun, Jong Chan-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorWon, Ho Youn-
dc.contributor.affiliatedAuthorYoun, Jong Chan-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorHong, Namki-
dc.citation.volume413-
dc.citation.number11-12-
dc.citation.startPage992-
dc.citation.endPage997-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.413(11-12) : 992-997, 2012-
dc.identifier.rimsid32015-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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