178 303

Cited 0 times in

N-terminal pro-B-type natriuretic peptide, left ventricular mass, and incident heart failure: Multi-Ethnic Study of Atherosclerosis.

DC FieldValueLanguage
dc.contributor.author최의영-
dc.date.accessioned2014-12-19T16:40:17Z-
dc.date.available2014-12-19T16:40:17Z-
dc.date.issued2012-
dc.identifier.issn1941-3289-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89969-
dc.description.abstractBACKGROUND: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) is associated with clinically overt heart failure (HF). However, whether it provides additive prognostic information for incident HF beyond traditional risk factors and left ventricular (LV) mass index among multi-ethnic asymptomatic individuals has not yet been determined. We studied the associations of plasma NT-proBNP and magnetic resonance imaging defined LV mass index with incident HF in an asymptomatic multi-ethnic population. METHODS AND RESULTS: A total of 5597 multi-ethnic participants without clinically apparent cardiovascular disease underwent baseline measurement of NT-proBNP and were followed for 5.5±1.1 years. Among them, 4163 also underwent baseline cardiac magnetic resonance imaging. During follow-up, 111 participants experienced incident HF. Higher NT-proBNP was significantly associated with incident HF, independent of baseline age, sex, ethnicity, systolic blood pressure, diabetes mellitus, smoking, estimated glomerular filtration rate, medications (anti-hypertensive and statin), LV mass index, and interim myocardial infarction (hazard ratio: 1.95 per 1U log NT-proBNP increment, 95% CI 1.54-2.46, P<0.001). This relationship held among different ethnic groups, non-Hispanic whites, African-Americans, and Hispanics. Most importantly, NT-proBNP provided additive prognostic value beyond both traditional risk factors and LV mass index for predicting incident HF (integrated discrimination index=0.046, P<0.001; net reclassification index; 6-year risk probability categorized by <3%, 3-10%, >10% =0.175, P=0.019; category-less net reclassification index=0.561, P<0.001). CONCLUSIONS: Plasma NT-proBNP provides incremental prognostic information beyond traditional risk factors and the magnetic resonance imaging-determined LV mass index for incident symptomatic HF in an asymptomatic multi-ethnic population.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCIRCULATION-HEART FAILURE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAfrican Americans/ethnology-
dc.subject.MESHAged-
dc.subject.MESHAsian Americans/ethnology-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHEuropean Continental Ancestry Group/ethnology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHeart Failure/diagnosis*-
dc.subject.MESHHeart Failure/epidemiology*-
dc.subject.MESHHeart Failure/ethnology-
dc.subject.MESHHispanic Americans/ethnology-
dc.subject.MESHHumans-
dc.subject.MESHHypertrophy, Left Ventricular/pathology*-
dc.subject.MESHIncidence-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNatriuretic Peptide, Brain/blood*-
dc.subject.MESHPeptide Fragments/blood*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.titleN-terminal pro-B-type natriuretic peptide, left ventricular mass, and incident heart failure: Multi-Ethnic Study of Atherosclerosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEui-Young Choi-
dc.contributor.googleauthorHossein Bahrami-
dc.contributor.googleauthorColin O. Wu-
dc.contributor.googleauthorPhilip Greenland-
dc.contributor.googleauthorMary Cushman-
dc.contributor.googleauthorLori B. Daniels-
dc.contributor.googleauthorAndre L.C. Almeida-
dc.contributor.googleauthorKihei Yoneyama-
dc.contributor.googleauthorAnders Opdahl-
dc.contributor.googleauthorAditya Jain-
dc.contributor.googleauthorMichael H. Criqui-
dc.contributor.googleauthorDavid Siscovick-
dc.contributor.googleauthorChristine Darwin-
dc.contributor.googleauthorAlan Maisel-
dc.contributor.googleauthorDavid A. Bluemke-
dc.contributor.googleauthorJoao A.C. Lima-
dc.identifier.doi23032197-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04165-
dc.relation.journalcodeJ00540-
dc.identifier.eissn1941-3297-
dc.identifier.pmid23032197-
dc.subject.keywordAfrican Americans/ethnology-
dc.subject.keywordAged-
dc.subject.keywordAsian Americans/ethnology-
dc.subject.keywordBiomarkers/blood-
dc.subject.keywordEuropean Continental Ancestry Group/ethnology-
dc.subject.keywordFemale-
dc.subject.keywordFollow-Up Studies-
dc.subject.keywordHeart Failure/diagnosis*-
dc.subject.keywordHeart Failure/epidemiology*-
dc.subject.keywordHeart Failure/ethnology-
dc.subject.keywordHispanic Americans/ethnology-
dc.subject.keywordHumans-
dc.subject.keywordHypertrophy, Left Ventricular/pathology*-
dc.subject.keywordIncidence-
dc.subject.keywordLongitudinal Studies-
dc.subject.keywordMagnetic Resonance Imaging-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNatriuretic Peptide, Brain/blood*-
dc.subject.keywordPeptide Fragments/blood*-
dc.subject.keywordPredictive Value of Tests-
dc.subject.keywordProspective Studies-
dc.subject.keywordRisk Factors-
dc.contributor.alternativeNameChoi, Eui Young-
dc.contributor.affiliatedAuthorChoi, Eui Young-
dc.citation.volume5-
dc.citation.number6-
dc.citation.startPage727-
dc.citation.endPage734-
dc.identifier.bibliographicCitationCIRCULATION-HEART FAILURE, Vol.5(6) : 727-734, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.