Cited 69 times in
N-terminal pro-B-type natriuretic peptide, left ventricular mass, and incident heart failure: Multi-Ethnic Study of Atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | 최의영 | - |
dc.date.accessioned | 2014-12-19T16:40:17Z | - |
dc.date.available | 2014-12-19T16:40:17Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1941-3289 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89969 | - |
dc.description.abstract | BACKGROUND: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) is associated with clinically overt heart failure (HF). However, whether it provides additive prognostic information for incident HF beyond traditional risk factors and left ventricular (LV) mass index among multi-ethnic asymptomatic individuals has not yet been determined. We studied the associations of plasma NT-proBNP and magnetic resonance imaging defined LV mass index with incident HF in an asymptomatic multi-ethnic population. METHODS AND RESULTS: A total of 5597 multi-ethnic participants without clinically apparent cardiovascular disease underwent baseline measurement of NT-proBNP and were followed for 5.5±1.1 years. Among them, 4163 also underwent baseline cardiac magnetic resonance imaging. During follow-up, 111 participants experienced incident HF. Higher NT-proBNP was significantly associated with incident HF, independent of baseline age, sex, ethnicity, systolic blood pressure, diabetes mellitus, smoking, estimated glomerular filtration rate, medications (anti-hypertensive and statin), LV mass index, and interim myocardial infarction (hazard ratio: 1.95 per 1U log NT-proBNP increment, 95% CI 1.54-2.46, P<0.001). This relationship held among different ethnic groups, non-Hispanic whites, African-Americans, and Hispanics. Most importantly, NT-proBNP provided additive prognostic value beyond both traditional risk factors and LV mass index for predicting incident HF (integrated discrimination index=0.046, P<0.001; net reclassification index; 6-year risk probability categorized by <3%, 3-10%, >10% =0.175, P=0.019; category-less net reclassification index=0.561, P<0.001). CONCLUSIONS: Plasma NT-proBNP provides incremental prognostic information beyond traditional risk factors and the magnetic resonance imaging-determined LV mass index for incident symptomatic HF in an asymptomatic multi-ethnic population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CIRCULATION-HEART FAILURE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | African Americans/ethnology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian Americans/ethnology | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | European Continental Ancestry Group/ethnology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Heart Failure/diagnosis* | - |
dc.subject.MESH | Heart Failure/epidemiology* | - |
dc.subject.MESH | Heart Failure/ethnology | - |
dc.subject.MESH | Hispanic Americans/ethnology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertrophy, Left Ventricular/pathology* | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Natriuretic Peptide, Brain/blood* | - |
dc.subject.MESH | Peptide Fragments/blood* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | N-terminal pro-B-type natriuretic peptide, left ventricular mass, and incident heart failure: Multi-Ethnic Study of Atherosclerosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eui-Young Choi | - |
dc.contributor.googleauthor | Hossein Bahrami | - |
dc.contributor.googleauthor | Colin O. Wu | - |
dc.contributor.googleauthor | Philip Greenland | - |
dc.contributor.googleauthor | Mary Cushman | - |
dc.contributor.googleauthor | Lori B. Daniels | - |
dc.contributor.googleauthor | Andre L.C. Almeida | - |
dc.contributor.googleauthor | Kihei Yoneyama | - |
dc.contributor.googleauthor | Anders Opdahl | - |
dc.contributor.googleauthor | Aditya Jain | - |
dc.contributor.googleauthor | Michael H. Criqui | - |
dc.contributor.googleauthor | David Siscovick | - |
dc.contributor.googleauthor | Christine Darwin | - |
dc.contributor.googleauthor | Alan Maisel | - |
dc.contributor.googleauthor | David A. Bluemke | - |
dc.contributor.googleauthor | Joao A.C. Lima | - |
dc.identifier.doi | 10.1161/CIRCHEARTFAILURE.112.968701 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04165 | - |
dc.relation.journalcode | J00540 | - |
dc.identifier.eissn | 1941-3297 | - |
dc.identifier.pmid | 23032197 | - |
dc.subject.keyword | African Americans/ethnology | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Asian Americans/ethnology | - |
dc.subject.keyword | Biomarkers/blood | - |
dc.subject.keyword | European Continental Ancestry Group/ethnology | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Follow-Up Studies | - |
dc.subject.keyword | Heart Failure/diagnosis* | - |
dc.subject.keyword | Heart Failure/epidemiology* | - |
dc.subject.keyword | Heart Failure/ethnology | - |
dc.subject.keyword | Hispanic Americans/ethnology | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hypertrophy, Left Ventricular/pathology* | - |
dc.subject.keyword | Incidence | - |
dc.subject.keyword | Longitudinal Studies | - |
dc.subject.keyword | Magnetic Resonance Imaging | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Natriuretic Peptide, Brain/blood* | - |
dc.subject.keyword | Peptide Fragments/blood* | - |
dc.subject.keyword | Predictive Value of Tests | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Risk Factors | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.citation.volume | 5 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 727 | - |
dc.citation.endPage | 734 | - |
dc.identifier.bibliographicCitation | CIRCULATION-HEART FAILURE, Vol.5(6) : 727-734, 2012 | - |
dc.identifier.rimsid | 32008 | - |
dc.type.rims | ART | - |
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