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Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery.

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author송종욱-
dc.contributor.author심재광-
dc.contributor.author양소영-
dc.contributor.author윤영남-
dc.date.accessioned2014-12-19T16:39:47Z-
dc.date.available2014-12-19T16:39:47Z-
dc.date.issued2012-
dc.identifier.issn1346-9843-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89954-
dc.description.abstractBACKGROUND: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). METHODS AND RESULTS: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1g bolus followed by infusion at 200mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4h was significantly less in the TA group. CONCLUSIONS: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnemia/complications*-
dc.subject.MESHAnemia/epidemiology-
dc.subject.MESHAntifibrinolytic Agents/therapeutic use-
dc.subject.MESHBlood Loss, Surgical/prevention & control*-
dc.subject.MESHBlood Transfusion*-
dc.subject.MESHComorbidity-
dc.subject.MESHCoronary Artery Bypass, Off-Pump*-
dc.subject.MESHCoronary Disease/epidemiology-
dc.subject.MESHCoronary Disease/surgery*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPlatelet Aggregation Inhibitors/therapeutic use*-
dc.subject.MESHTime Factors-
dc.subject.MESHTranexamic Acid/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.titleEffect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSo Woon Ahn-
dc.contributor.googleauthorJae Kwang Shim-
dc.contributor.googleauthorYoung Nam Youn-
dc.contributor.googleauthorJong Wook Song-
dc.contributor.googleauthorSo Young Yang-
dc.contributor.googleauthorSung Chan Chung-
dc.contributor.googleauthorYoung Lan Kwak-
dc.identifier.doi22033349-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02060-
dc.contributor.localIdA02205-
dc.contributor.localIdA02291-
dc.contributor.localIdA02576-
dc.relation.journalcodeJ00534-
dc.identifier.eissn1347-4820-
dc.identifier.pmid22033349-
dc.subject.keywordAnemia-
dc.subject.keywordDual antiplatelet therapy-
dc.subject.keywordOff-pump coronary artery bypass-
dc.subject.keywordTranexamic acid-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYang, So Young-
dc.contributor.alternativeNameYoun, Young Nam-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorSong, Jong Wook-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYang, So Young-
dc.contributor.affiliatedAuthorYoun, Young Nam-
dc.citation.volume76-
dc.citation.number1-
dc.citation.startPage96-
dc.citation.endPage101-
dc.identifier.bibliographicCitationCIRCULATION JOURNAL, Vol.76(1) : 96-101, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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