Cited 16 times in
Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 양소영 | - |
dc.contributor.author | 윤영남 | - |
dc.date.accessioned | 2014-12-19T16:39:47Z | - |
dc.date.available | 2014-12-19T16:39:47Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89954 | - |
dc.description.abstract | BACKGROUND: Anemia is not rare in patients presenting for coronary artery bypass graft surgery (CABG) and as these patients are frequently on dual antiplatelet therapy (DAPT), the coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued DAPT until within 5 days of off-pump CABG (OPCAB). METHODS AND RESULTS: Seventy-six anemic patients were randomized into 2 groups: TA group receiving TA (1g bolus followed by infusion at 200mg/h) and a Control group receiving the same volume of saline. The amount of blood loss and transfusion requirement during, and at 4 and 24h after the operation were assessed. Patients' characteristics and operative data were similar between the groups. During the perioperative period, which combined the intraoperative and postoperative 24h data, the TA group received significantly smaller amounts of packed red blood cells and fresh frozen plasma. Total amount of perioperative blood loss was similar between the groups, although the blood loss during the postoperative 4h was significantly less in the TA group. CONCLUSIONS: TA infusion could reduce the amount of transfusion during the perioperative period in patients with preoperative anemia who continue DAPT until within 5 days of OPCAB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anemia/complications* | - |
dc.subject.MESH | Anemia/epidemiology | - |
dc.subject.MESH | Antifibrinolytic Agents/therapeutic use | - |
dc.subject.MESH | Blood Loss, Surgical/prevention & control* | - |
dc.subject.MESH | Blood Transfusion* | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump* | - |
dc.subject.MESH | Coronary Disease/epidemiology | - |
dc.subject.MESH | Coronary Disease/surgery* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/therapeutic use* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tranexamic Acid/therapeutic use* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | So Woon Ahn | - |
dc.contributor.googleauthor | Jae Kwang Shim | - |
dc.contributor.googleauthor | Young Nam Youn | - |
dc.contributor.googleauthor | Jong Wook Song | - |
dc.contributor.googleauthor | So Young Yang | - |
dc.contributor.googleauthor | Sung Chan Chung | - |
dc.contributor.googleauthor | Young Lan Kwak | - |
dc.identifier.doi | 10.1253/circj.cj-11-0811 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02291 | - |
dc.contributor.localId | A02576 | - |
dc.relation.journalcode | J00534 | - |
dc.identifier.eissn | 1347-4820 | - |
dc.identifier.pmid | 22033349 | - |
dc.subject.keyword | Anemia | - |
dc.subject.keyword | Dual antiplatelet therapy | - |
dc.subject.keyword | Off-pump coronary artery bypass | - |
dc.subject.keyword | Tranexamic acid | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yang, So Young | - |
dc.contributor.alternativeName | Youn, Young Nam | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yang, So Young | - |
dc.contributor.affiliatedAuthor | Youn, Young Nam | - |
dc.citation.volume | 76 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 96 | - |
dc.citation.endPage | 101 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, Vol.76(1) : 96-101, 2012 | - |
dc.identifier.rimsid | 31997 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.