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Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study.
DC Field | Value | Language |
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dc.contributor.author | 권혁문 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2014-12-19T16:39:38Z | - |
dc.date.available | 2014-12-19T16:39:38Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89949 | - |
dc.description.abstract | BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) after implantation of drug-eluting coronary stents remains undetermined. We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of drug-eluting stents. METHODS AND RESULTS: We randomly assigned 1443 patients undergoing implantation of drug-eluting stents to receive 6- or 12-month DAPT (in a 1:1 ratio). The primary end point was a target vessel failure, defined as the composite of cardiac death, myocardial infarction, or ischemia-driven target vessel revascularization at 12 months. Rates of target vessel failure at 12 months were 4.8% in the 6-month DAPT group and 4.3% in the 12-month DAPT group (the upper limit of 1-sided 95% confidence interval, 2.4%; P=0.001 for noninferiority with a predefined noninferiority margin of 4.0%). Although stent thrombosis tended to occur more frequently in the 6-month DAPT group than in the 12-month group (0.9% versus 0.1%; hazard ratio, 6.02; 95% confidence interval, 0.72-49.96; P=0.10), the risk of death or myocardial infarction did not differ in the 2 groups (2.4% versus 1.9%; hazard ratio, 1.21; 95% confidence interval, 0.60-2.47; P=0.58). In the prespecified subgroup analysis, target vessel failure occurred more frequently in the 6-month DAPT group than in the 12-month group (hazard ratio, 3.16; 95% confidence interval, 1.42-7.03; P=0.005) among diabetic patients. CONCLUSIONS: Six-month DAPT did not increase the risk of target vessel failure at 12 months after implantation of drug-eluting stents compared with 12-month DAPT. However, the noninferiority margin was wide, and the study was underpowered for death or myocardial infarction. Our results need to be confirmed in larger trials. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00698607. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CIRCULATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyeon-Cheol Gwon | - |
dc.contributor.googleauthor | Joo-Yong Hahn | - |
dc.contributor.googleauthor | Kyung Woo Park | - |
dc.contributor.googleauthor | Young Bin Song | - |
dc.contributor.googleauthor | In-Ho Chae | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.contributor.googleauthor | Kyoo-Rok Han | - |
dc.contributor.googleauthor | Jin-Ho Choi | - |
dc.contributor.googleauthor | Seung-Hyuk Choi | - |
dc.contributor.googleauthor | Hyun-Jae Kang | - |
dc.contributor.googleauthor | Bon-Kwon Koo | - |
dc.contributor.googleauthor | Taehoon Ahn | - |
dc.contributor.googleauthor | Jung-Han Yoon | - |
dc.contributor.googleauthor | Myung-Ho Jeong | - |
dc.contributor.googleauthor | Taek-Jong Hong | - |
dc.contributor.googleauthor | Woo-Young Chung | - |
dc.contributor.googleauthor | Young-Jin Choi | - |
dc.contributor.googleauthor | Seung-Ho Hur | - |
dc.contributor.googleauthor | Hyuck-Moon Kwon | - |
dc.contributor.googleauthor | Dong-Woon Jeon | - |
dc.contributor.googleauthor | Byung-Ok Kim | - |
dc.contributor.googleauthor | Si-Hoon Park | - |
dc.contributor.googleauthor | Nam-Ho Lee | - |
dc.contributor.googleauthor | Hui-Kyung Jeon | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.111.059022 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00260 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00533 | - |
dc.identifier.eissn | 1524-4539 | - |
dc.identifier.pmid | drug-eluting stents ; platelet aggregation inhibitors ; stents ; thrombosis | - |
dc.subject.keyword | drug-eluting stents | - |
dc.subject.keyword | platelet aggregation inhibitors | - |
dc.subject.keyword | stents | - |
dc.subject.keyword | thrombosis | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 125 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 505 | - |
dc.citation.endPage | 513 | - |
dc.identifier.bibliographicCitation | CIRCULATION, Vol.125(3) : 505-513, 2012 | - |
dc.identifier.rimsid | 31993 | - |
dc.type.rims | ART | - |
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