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Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery.

DC FieldValueLanguage
dc.contributor.author심재광-
dc.contributor.author양소영-
dc.contributor.author유영철-
dc.contributor.author이삭-
dc.contributor.author곽영란-
dc.contributor.author김종찬-
dc.date.accessioned2014-12-19T16:39:26Z-
dc.date.available2014-12-19T16:39:26Z-
dc.date.issued2012-
dc.identifier.issn0012-3692-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89943-
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the lung-protective effect of combined remote ischemic preconditioning (RIPCpre) and postconditioning (RIPCpost) in patients undergoing complex valvular heart surgery. METHODS: In this randomized, placebo-controlled, double-blind trial, 54 patients were assigned to an RIPCpre plus RIPCpost group or a control group (1:1). Patients in the RIPCpre plus RIPCpost group received three 10-min cycles of right-side lower-limb ischemia of 250 mm Hg at both 10 min after anesthetic induction and weaning from cardiopulmonary bypass. The primary end point was to compare postoperative Pao(2)/Fio(2). Secondary end points were to compare pulmonary variables, incidence of acute lung injury, and inflammatory cytokines. RESULTS: In both groups, Pao(2)/Fio(2) at 24 h postoperation was significantly decreased compared with each corresponding baseline value. However, intergroup comparisons of pulmonary variables, including Pao(2)/Fio(2) and incidence of acute lung injury, revealed no significant differences. Serum levels of IL-6, IL-8, IL-10, and tumor necrosis factor-α were all significantly increased in both groups compared with each corresponding baseline value, without any significant intergroup differences. There were also no significant differences in transpulmonary gradient of IL-6, IL-10, and tumor necrosis factor-α between the groups. CONCLUSIONS: RIPCpre plus RIPCpost as tested in this randomized controlled trial did not provide significant pulmonary benefit following complex valvular cardiac surgery.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCHEST-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Lung Injury/diagnosis-
dc.subject.MESHAcute Lung Injury/etiology-
dc.subject.MESHAcute Lung Injury/prevention & control-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCardiopulmonary Bypass/adverse effects-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases/complications-
dc.subject.MESHHeart Valve Diseases/physiopathology*-
dc.subject.MESHHeart Valve Diseases/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHIschemic Postconditioning/methods*-
dc.subject.MESHIschemic Preconditioning/methods*-
dc.subject.MESHLower Extremity/blood supply*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHPulmonary Gas Exchange/physiology-
dc.subject.MESHPulmonary Ventilation/physiology*-
dc.subject.MESHReperfusion Injury/diagnosis-
dc.subject.MESHReperfusion Injury/etiology-
dc.subject.MESHReperfusion Injury/prevention & control-
dc.titleEffect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorJong-Chan Kim-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorYoung-Chul Yoo-
dc.contributor.googleauthorSo-Young Yang-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi22281799-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02205-
dc.contributor.localIdA02291-
dc.contributor.localIdA02484-
dc.contributor.localIdA02807-
dc.contributor.localIdA00172-
dc.contributor.localIdA00929-
dc.relation.journalcodeJ00520-
dc.identifier.eissn1931-3543-
dc.identifier.pmid22281799-
dc.identifier.urlhttp://journal.publications.chestnet.org/article.aspx?articleid=1262340-
dc.subject.keywordAcute Lung Injury/diagnosis-
dc.subject.keywordAcute Lung Injury/etiology-
dc.subject.keywordAcute Lung Injury/prevention & control-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordCardiopulmonary Bypass/adverse effects-
dc.subject.keywordDouble-Blind Method-
dc.subject.keywordFemale-
dc.subject.keywordHeart Valve Diseases/complications-
dc.subject.keywordHeart Valve Diseases/physiopathology*-
dc.subject.keywordHeart Valve Diseases/surgery*-
dc.subject.keywordHumans-
dc.subject.keywordIschemic Postconditioning/methods*-
dc.subject.keywordIschemic Preconditioning/methods*-
dc.subject.keywordLower Extremity/blood supply*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordProspective Studies-
dc.subject.keywordPulmonary Gas Exchange/physiology-
dc.subject.keywordPulmonary Ventilation/physiology*-
dc.subject.keywordReperfusion Injury/diagnosis-
dc.subject.keywordReperfusion Injury/etiology-
dc.subject.keywordReperfusion Injury/prevention & control-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameYang, So Young-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.alternativeNameLee, Sak-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKim, Jong Chan-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorYang, So Young-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.contributor.affiliatedAuthorLee, Sak-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorKim, Jong Chan-
dc.citation.volume142-
dc.citation.number2-
dc.citation.startPage467-
dc.citation.endPage475-
dc.identifier.bibliographicCitationCHEST, Vol.142(2) : 467-475, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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