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Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심재광 | - |
dc.contributor.author | 양소영 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 이삭 | - |
dc.contributor.author | 곽영란 | - |
dc.date.accessioned | 2014-12-19T16:39:26Z | - |
dc.date.available | 2014-12-19T16:39:26Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0012-3692 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89943 | - |
dc.description.abstract | BACKGROUND: The aim of this study was to evaluate the lung-protective effect of combined remote ischemic preconditioning (RIPCpre) and postconditioning (RIPCpost) in patients undergoing complex valvular heart surgery. METHODS: In this randomized, placebo-controlled, double-blind trial, 54 patients were assigned to an RIPCpre plus RIPCpost group or a control group (1:1). Patients in the RIPCpre plus RIPCpost group received three 10-min cycles of right-side lower-limb ischemia of 250 mm Hg at both 10 min after anesthetic induction and weaning from cardiopulmonary bypass. The primary end point was to compare postoperative Pao(2)/Fio(2). Secondary end points were to compare pulmonary variables, incidence of acute lung injury, and inflammatory cytokines. RESULTS: In both groups, Pao(2)/Fio(2) at 24 h postoperation was significantly decreased compared with each corresponding baseline value. However, intergroup comparisons of pulmonary variables, including Pao(2)/Fio(2) and incidence of acute lung injury, revealed no significant differences. Serum levels of IL-6, IL-8, IL-10, and tumor necrosis factor-α were all significantly increased in both groups compared with each corresponding baseline value, without any significant intergroup differences. There were also no significant differences in transpulmonary gradient of IL-6, IL-10, and tumor necrosis factor-α between the groups. CONCLUSIONS: RIPCpre plus RIPCpost as tested in this randomized controlled trial did not provide significant pulmonary benefit following complex valvular cardiac surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CHEST | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Lung Injury/diagnosis | - |
dc.subject.MESH | Acute Lung Injury/etiology | - |
dc.subject.MESH | Acute Lung Injury/prevention & control | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiopulmonary Bypass/adverse effects | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Valve Diseases/complications | - |
dc.subject.MESH | Heart Valve Diseases/physiopathology* | - |
dc.subject.MESH | Heart Valve Diseases/surgery* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ischemic Postconditioning/methods* | - |
dc.subject.MESH | Ischemic Preconditioning/methods* | - |
dc.subject.MESH | Lower Extremity/blood supply* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Pulmonary Gas Exchange/physiology | - |
dc.subject.MESH | Pulmonary Ventilation/physiology* | - |
dc.subject.MESH | Reperfusion Injury/diagnosis | - |
dc.subject.MESH | Reperfusion Injury/etiology | - |
dc.subject.MESH | Reperfusion Injury/prevention & control | - |
dc.title | Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Jong-Chan Kim | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Young-Chul Yoo | - |
dc.contributor.googleauthor | So-Young Yang | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 22281799 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02291 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A02807 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A00929 | - |
dc.relation.journalcode | J00520 | - |
dc.identifier.eissn | 1931-3543 | - |
dc.identifier.pmid | 22281799 | - |
dc.identifier.url | http://journal.publications.chestnet.org/article.aspx?articleid=1262340 | - |
dc.subject.keyword | Acute Lung Injury/diagnosis | - |
dc.subject.keyword | Acute Lung Injury/etiology | - |
dc.subject.keyword | Acute Lung Injury/prevention & control | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Cardiopulmonary Bypass/adverse effects | - |
dc.subject.keyword | Double-Blind Method | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Heart Valve Diseases/complications | - |
dc.subject.keyword | Heart Valve Diseases/physiopathology* | - |
dc.subject.keyword | Heart Valve Diseases/surgery* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Ischemic Postconditioning/methods* | - |
dc.subject.keyword | Ischemic Preconditioning/methods* | - |
dc.subject.keyword | Lower Extremity/blood supply* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Pulmonary Gas Exchange/physiology | - |
dc.subject.keyword | Pulmonary Ventilation/physiology* | - |
dc.subject.keyword | Reperfusion Injury/diagnosis | - |
dc.subject.keyword | Reperfusion Injury/etiology | - |
dc.subject.keyword | Reperfusion Injury/prevention & control | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Yang, So Young | - |
dc.contributor.alternativeName | Yoo, Young Chul | - |
dc.contributor.alternativeName | Lee, Sak | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Yang, So Young | - |
dc.contributor.affiliatedAuthor | Yoo, Young Chul | - |
dc.contributor.affiliatedAuthor | Lee, Sak | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.citation.volume | 142 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 467 | - |
dc.citation.endPage | 475 | - |
dc.identifier.bibliographicCitation | CHEST, Vol.142(2) : 467-475, 2012 | - |
dc.identifier.rimsid | 31989 | - |
dc.type.rims | ART | - |
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