Cited 31 times in
DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.
DC Field | Value | Language |
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dc.contributor.author | 정준 | - |
dc.date.accessioned | 2014-12-19T16:38:19Z | - |
dc.date.available | 2014-12-19T16:38:19Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89907 | - |
dc.description.abstract | TGF-β1 is a multifunctional cytokine that mediates diverse biological processes. However, the mechanisms by which the intracellular signals of TGF-β1 are terminated are not well understood. Here, we demonstrate that DRAK2 serves as a TGF-β1-inducible antagonist of TGF-β signaling. TGF-β1 stimulation rapidly induces DRAK2 expression and enhances endogenous interaction of the type I TGF-β receptor with DRAK2, thereby blocking R-Smads recruitment. Depletion of DRAK2 expression markedly augmented the intensity and the extent of TGF-β1 responses. Furthermore, a high level of DRAK2 expression was observed in basal-like and HER2-enriched breast tumors and cell lines, and depletion of DRAK2 expression suppressed the tumorigenic ability of breast cancer cells. Thus, these studies define a function for DRAK2 as an intrinsic intracellular antagonist participating in the negative feedback loop to control TGF-β1 responses, and aberrant expression of DRAK2 increases tumorigenic potential, in part, through the inhibition of TGF-β1 tumor suppressor activity. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Kyung-Min Yang | - |
dc.contributor.googleauthor | Wonjoo Kim | - |
dc.contributor.googleauthor | Eunjin Bae | - |
dc.contributor.googleauthor | Jungsoo Gim | - |
dc.contributor.googleauthor | Brian M. Weist | - |
dc.contributor.googleauthor | Yunshin Jung | - |
dc.contributor.googleauthor | Ja-Shil Hyun | - |
dc.contributor.googleauthor | Jennifer B. Hernandez | - |
dc.contributor.googleauthor | Sun-Hee Leem | - |
dc.contributor.googleauthor | Taesung Park | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Craig M. Walsh | - |
dc.contributor.googleauthor | Seong-Jin Kim | - |
dc.identifier.doi | 10.1016/j.celrep.2012.09.028 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S2211124712003324 | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.citation.volume | 2 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1286 | - |
dc.citation.endPage | 1299 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.2(5) : 1286-1299, 2012 | - |
dc.identifier.rimsid | 31975 | - |
dc.type.rims | ART | - |
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