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AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.

Authors
 Yon Hui Kim  ;  Han Liang  ;  Xiuping Liu  ;  Ju-Seog Lee  ;  Jae Yong Cho  ;  Jae-Ho Cheong  ;  Hoguen Kim  ;  Min Li  ;  Thomas J. Downey  ;  Matthew D. Dyer  ;  Yongming Sun  ;  Jingtao Sun  ;  Ellen M. Beasley  ;  Hyun Cheol Chung  ;  Sung Hoon Noh  ;  John N. Weinstein  ;  Chang-Gong Liu  ;  Garth Powis 
Citation
 Cancer Research, Vol.72(10) : 2512-2521, 2012 
Journal Title
 Cancer Research 
ISSN
 0008-5472 
Issue Date
2012
Abstract
Gastric cancer is the most common cancer in Asia and most developing countries. Despite the use of multimodality therapeutics, it remains the second leading cause of cancer death in the world. To identify the molecular underpinnings of gastric cancer in the Asian population, we applied an RNA-sequencing approach to gastric tumor and noncancerous specimens, generating 680 million informative short reads to quantitatively characterize the entire transcriptome of gastric cancer (including mRNAs and miRNAs). A multilayer analysis was then developed to identify multiple types of transcriptional aberrations associated with different stages of gastric cancer, including differentially expressed mRNAs, recurrent somatic mutations, and key differentially expressed miRNAs. Through this approach, we identified the central metabolic regulator AMP-activated protein kinase (AMPK)α as a potential functional target in Asian gastric cancer. Furthermore, we experimentally showed the translational relevance of this gene as a potential therapeutic target for early-stage gastric cancer in Asian patients. Together, our findings not only provide a valuable information resource for identifying and elucidating the molecular mechanisms of Asian gastric cancer, but also represent a general integrative framework to develop more effective therapeutic targets.
Files in This Item:
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DOI
10.1158/0008-5472.CAN-11-3870
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ho Keun(김호근)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89873
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