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Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes.
DC Field | Value | Language |
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dc.contributor.author | 김승일 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이준상 | - |
dc.contributor.author | 황혜원 | - |
dc.contributor.author | 구자승 | - |
dc.date.accessioned | 2014-12-19T16:35:33Z | - |
dc.date.available | 2014-12-19T16:35:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89820 | - |
dc.description.abstract | In order to investigate the implications of cyclooxygenase-2 (COX-2) expression in combination with Ki-67 on breast cancer outcomes, the COX-2 and Ki-67 expression levels and other clinicopathologic parameters were investigated in 861 breast cancers. Clinicopathological parameters and survival were investigated in association with the expression levels of both COX-2 and Ki-67 using univariate and multivariate analyses. COX-2 expression was positive in 493 (57.3%) of invasive tumors. COX-2 was associated with favorable markers, but was not related to survival outcome by itself. However, COX-2 in proliferative tumors [COX-2(+)/Ki-67(+)] were significantly associated with unfavorable factors and the worst survival, but COX-2 in non-proliferative tumors [COX-2(+)/Ki-67(-)] showed significantly favorable parameters and better outcomes. COX-2(-)/Ki-67(any) showed intermediate prognosis. The statistical significance was maintained in stage-matched and multivariate analyses. The results of present study suggest that COX-2 expression is a common event in breast cancers and may play in a different ways by the proliferation status of the tumor cells. Further studies should be carried out to verify the role of COX-2 by proliferative conditions of breast tumor cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Byeong-Woo Park | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Jun Sang Lee | - |
dc.contributor.googleauthor | Hyewon Hwang | - |
dc.contributor.googleauthor | Seung Il Kim | - |
dc.contributor.googleauthor | Kyong Sik Lee | - |
dc.identifier.doi | 10.1007/s10549-012-1971-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00658 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03175 | - |
dc.contributor.localId | A04494 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | Breast neoplasms ; Cyclooxygenase-2 ; Proliferation ; Ki-67 ; Prognosis ; Progression | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10549-012-1971-2 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Cyclooxygenase-2 | - |
dc.subject.keyword | Proliferation | - |
dc.subject.keyword | Ki-67 | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Progression | - |
dc.contributor.alternativeName | Kim, Seung Il | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Jun Sang | - |
dc.contributor.alternativeName | Hwang, Hye Won | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Seung Il | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lee, Jun Sang | - |
dc.contributor.affiliatedAuthor | Hwang, Hye Won | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 133 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 741 | - |
dc.citation.endPage | 751 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.133(2) : 741-751, 2012 | - |
dc.identifier.rimsid | 31925 | - |
dc.type.rims | ART | - |
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