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Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes.

DC FieldValueLanguage
dc.contributor.author김승일-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박형석-
dc.contributor.author양우익-
dc.contributor.author이준상-
dc.contributor.author황혜원-
dc.contributor.author구자승-
dc.date.accessioned2014-12-19T16:35:33Z-
dc.date.available2014-12-19T16:35:33Z-
dc.date.issued2012-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89820-
dc.description.abstractIn order to investigate the implications of cyclooxygenase-2 (COX-2) expression in combination with Ki-67 on breast cancer outcomes, the COX-2 and Ki-67 expression levels and other clinicopathologic parameters were investigated in 861 breast cancers. Clinicopathological parameters and survival were investigated in association with the expression levels of both COX-2 and Ki-67 using univariate and multivariate analyses. COX-2 expression was positive in 493 (57.3%) of invasive tumors. COX-2 was associated with favorable markers, but was not related to survival outcome by itself. However, COX-2 in proliferative tumors [COX-2(+)/Ki-67(+)] were significantly associated with unfavorable factors and the worst survival, but COX-2 in non-proliferative tumors [COX-2(+)/Ki-67(-)] showed significantly favorable parameters and better outcomes. COX-2(-)/Ki-67(any) showed intermediate prognosis. The statistical significance was maintained in stage-matched and multivariate analyses. The results of present study suggest that COX-2 expression is a common event in breast cancers and may play in a different ways by the proliferation status of the tumor cells. Further studies should be carried out to verify the role of COX-2 by proliferative conditions of breast tumor cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorJun Sang Lee-
dc.contributor.googleauthorHyewon Hwang-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorKyong Sik Lee-
dc.identifier.doi10.1007/s10549-012-1971-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00658-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01753-
dc.contributor.localIdA02300-
dc.contributor.localIdA03175-
dc.contributor.localIdA04494-
dc.contributor.localIdA00198-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmidBreast neoplasms ; Cyclooxygenase-2 ; Proliferation ; Ki-67 ; Prognosis ; Progression-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10549-012-1971-2-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordCyclooxygenase-2-
dc.subject.keywordProliferation-
dc.subject.keywordKi-67-
dc.subject.keywordPrognosis-
dc.subject.keywordProgression-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Jun Sang-
dc.contributor.alternativeNameHwang, Hye Won-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Jun Sang-
dc.contributor.affiliatedAuthorHwang, Hye Won-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume133-
dc.citation.number2-
dc.citation.startPage741-
dc.citation.endPage751-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.133(2) : 741-751, 2012-
dc.identifier.rimsid31925-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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