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c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1.
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2014-12-19T16:33:54Z | - |
dc.date.available | 2014-12-19T16:33:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89768 | - |
dc.description.abstract | Leukotactin(Lkn)-1 is a CC chemokine and is upregulated in macrophages in response to Mycobacterium tuberculosis (MTB) infection. We investigated whether mitogen-activated protein kinases (MAPKs) are involved in MTB-induced expression of Lkn-1. The up-regulation of Lkn-1 by infection with MTB was inhibited in cells treated with inhibitors specific for JNK (SP600125) or p38 MAPK (SB202190). Since the up-regulation of Lkn-1 by MTB has been reported to be mediated by the PI3-K/PDK1/Akt signaling, we examined whether JNK and/or p38 MAPK are also involved in this signal pathway. MTB-induced Akt phosphorylation was blocked by treatment with JNK- or p38 MAPK-specific inhibitors implying that p38 and JNK are upstream of Akt. In addition, treatment with the PI3-K-specific inhibitor inhibited MTB-stimulated activation of JNK or p38 MAPK implying that PI3-K is upstream of JNK and p38 MAPK. These results collectively suggest that JNK and p38 MAPK are involved in the signal pathway responsible for MTB-induced up-regulation of Lkn-1. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anthracenes/pharmacology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chemokines, CC/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imidazoles/pharmacology | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | Mycobacterium tuberculosis/enzymology | - |
dc.subject.MESH | Mycobacterium tuberculosis/metabolism* | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Pyridines/pharmacology | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Tuberculosis/metabolism | - |
dc.subject.MESH | Tuberculosis/pathology | - |
dc.subject.MESH | Up-Regulation/drug effects | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/metabolism* | - |
dc.title | c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jang-Eun Cho | - |
dc.contributor.googleauthor | Sangjung Park | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Hyeyoung Lee | - |
dc.contributor.googleauthor | Yoon Suk Kim | - |
dc.identifier.doi | 23101513 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 23101513 | - |
dc.subject.keyword | JNK | - |
dc.subject.keyword | Leukotactin-1 | - |
dc.subject.keyword | Macrophage | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | p38 MAPK | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.citation.volume | 45 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 583 | - |
dc.citation.endPage | 588 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.45(10) : 583-588, 2012 | - |
dc.identifier.rimsid | 31894 | - |
dc.type.rims | ART | - |
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