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c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1.

Authors
 Jang-Eun Cho  ;  Sangjung Park  ;  Sang-Nae Cho  ;  Hyeyoung Lee  ;  Yoon Suk Kim 
Citation
 BMB REPORTS, Vol.45(10) : 583-588, 2012 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2012
MeSH
Anthracenes/pharmacology ; Cell Line, Tumor ; Chemokines, CC/metabolism* ; Humans ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism* ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/metabolism* ; Phosphatidylinositol 3-Kinases ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Pyridines/pharmacology ; Signal Transduction/drug effects ; Tuberculosis/metabolism ; Tuberculosis/pathology ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism*
Keywords
JNK ; Leukotactin-1 ; Macrophage ; Mycobacterium tuberculosis ; p38 MAPK
Abstract
Leukotactin(Lkn)-1 is a CC chemokine and is upregulated in macrophages in response to Mycobacterium tuberculosis (MTB) infection. We investigated whether mitogen-activated protein kinases (MAPKs) are involved in MTB-induced expression of Lkn-1. The up-regulation of Lkn-1 by infection with MTB was inhibited in cells treated with inhibitors specific for JNK (SP600125) or p38 MAPK (SB202190). Since the up-regulation of Lkn-1 by MTB has been reported to be mediated by the PI3-K/PDK1/Akt signaling, we examined whether JNK and/or p38 MAPK are also involved in this signal pathway. MTB-induced Akt phosphorylation was blocked by treatment with JNK- or p38 MAPK-specific inhibitors implying that p38 and JNK are upstream of Akt. In addition, treatment with the PI3-K-specific inhibitor inhibited MTB-stimulated activation of JNK or p38 MAPK implying that PI3-K is upstream of JNK and p38 MAPK. These results collectively suggest that JNK and p38 MAPK are involved in the signal pathway responsible for MTB-induced up-regulation of Lkn-1.
Files in This Item:
T201203547.pdf Download
DOI
23101513
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89768
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