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Association of plasma osteoprotegerin levels with stroke severity and functional outcome in acute ischaemic stroke patients

Authors
 Tae-Jin Song  ;  Jinkwon Kim  ;  Seung-Hee Yang  ;  Ji Hye Park  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Ok-Hee Lee  ;  Young Dae Kim  ;  Hyo Suk Nam  ;  Ji Hoe Heo 
Citation
 BIOMARKERS, Vol.17(8) : 738-744, 2012 
Journal Title
 BIOMARKERS 
ISSN
 1354-750X 
Issue Date
2012
MeSH
Acute Disease ; Aged ; Biomarkers/blood* ; Female ; Humans ; Ischemia/complications ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Osteoprotegerin/blood* ; Prognosis ; Risk Factors ; Severity of Illness Index ; Stroke/blood* ; Stroke/diagnosis ; Stroke/etiology
Keywords
Stroke ; osteoprotegerin ; functional outcome ; stroke severity
Abstract
Osteoprotegerin (OPG) is known to regulate processes involved in vascular injury and inflammation. We investigated the relationship between plasma OPG levels and stroke subtype, stroke severity at admission and functional outcome at 3 months in 172 patients with acute ischaemic stroke. Patients with large artery atherosclerosis and those with multiple causes had higher plasma OPG levels than patients with lacune. Increased plasma OPG levels were independently associated with more severe stroke and poor functional outcome. These results suggest pleiotropic roles of OPG in mediating atherosclerosis and ischaemic brain injury. OPG is a potential biomarker for predicting neurologic outcome in stroke.
Full Text
http://informahealthcare.com/doi/abs/10.3109/1354750X.2012.727027
DOI
23030274
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Ji Hye(박지혜)
Song, Tae Jin(송태진)
Yang, Seung Hee(양승희)
Lee, Ok Hee(이옥희)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89725
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