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Immunogenicity of recombinant human erythropoietin in Korea: A two-year cross-sectional study

DC Field Value Language
dc.contributor.author하성규-
dc.contributor.author유태현-
dc.date.accessioned2014-12-19T16:32:21Z-
dc.date.available2014-12-19T16:32:21Z-
dc.date.issued2012-
dc.identifier.issn1045-1056-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89720-
dc.description.abstractImmunogenicity of erythropoietin (EPO) is related with pure red cell aplasia (PRCA). We sought to determine the prevalence of antibody (Ab)-mediated PRCA in Korea and threshold diagnostic criteria by dual parameters: Ab titer and neutralizing activity. This study was a multi-center, cross-sectional study for two years. In the first year study (1 YS), 209 samples suspected to be EPO resistance were collected. In the second year study (2 YS), all the patients who consented to participate (N = 946) were enrolled. In 1 YS, we found three and six serum samples that were positive and borderline for anti-EPO Abs, respectively. The first three patients had neutralizing activity (NT) and were diagnosed as PRCA. In 2 YS, seven patients were anti-EPO positives and six had borderline levels. Among them, one patient with NT was diagnosed as PRCA and one with NT as aplastic anemia. The prevalence of PRCA was 0.106%. The correlation analysis of the 22 patients who had anti-EPO Ab showed that dual crossed cut-off lines (anti-EPO Ab titer ≥ 40 ng/ml, % NT ≥ 25%) were able to clearly isolate red cell aplasia. We suggest novel diagnostic criteria for diagnosis and prediction of Ab-mediated PRCA with data from both Ab titer assays and NT bioassays.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBIOLOGICALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHErythropoietin/immunology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecombinant Proteins/immunology-
dc.titleImmunogenicity of recombinant human erythropoietin in Korea: A two-year cross-sectional study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSug-Kyun Shin-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorSung Kyu Ha-
dc.contributor.googleauthorYoung-Il Jo-
dc.contributor.googleauthorTae-Won Lee-
dc.contributor.googleauthorYoung Sook Lee-
dc.contributor.googleauthorYang-Wook Kim-
dc.contributor.googleauthorDae Joong Kim-
dc.contributor.googleauthorJin Kuk Kim-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorKyu-Beck Lee-
dc.contributor.googleauthorSeung Ok Choi-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorKang Wook Lee-
dc.contributor.googleauthorSung-Jo Kim-
dc.contributor.googleauthorSang Kyum Kim-
dc.contributor.googleauthorTae-Hwe Heo-
dc.identifier.doi22391230-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04252-
dc.contributor.localIdA02110-
dc.contributor.localIdA02526-
dc.relation.journalcodeJ00307-
dc.identifier.eissn1095-8320-
dc.identifier.pmid22391230-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1045105612000279-
dc.subject.keywordAntibody-
dc.subject.keywordEnd-stage renal disease-
dc.subject.keywordErythropoietin-
dc.subject.keywordImmunogenicity-
dc.subject.keywordPure red cell aplasia-
dc.contributor.alternativeNameHa, Sung Kyu-
dc.contributor.alternativeNameShin, Sug Kyun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHa, Sung Kyu-
dc.contributor.affiliatedAuthorShin, Sug Kyun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.citation.volume40-
dc.citation.number4-
dc.citation.startPage254-
dc.citation.endPage261-
dc.identifier.bibliographicCitationBIOLOGICALS, Vol.40(4) : 254-261, 2012-
dc.identifier.rimsid31868-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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