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Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis.
DC Field | Value | Language |
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dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박성하 | - |
dc.date.accessioned | 2014-12-19T16:30:37Z | - |
dc.date.available | 2014-12-19T16:30:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89665 | - |
dc.description.abstract | OBJECTIVES: The soluble receptor for advanced glycation end products (sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response. In contrast, extracellular newly identified RAGE-binding protein (EN-RAGE) contributes to increased atherosclerosis as a pro-inflammatory ligand for RAGE. We determined the levels of sRAGE and EN-RAGE in peritoneal dialysis (PD) patients and evaluated their relationship with carotid atherosclerosis. METHODS: A cross-sectional study was performed in 91 PD patients and 29 control subjects. Carotid IMT (cIMT) and abdominal aortic vascular calcification score (VCS) were evaluated using high-resolution B-mode ultrasonography and plain radiographic film of the lateral abdomen. RESULTS: Plasma sRAGE and EN-RAGE levels were more than twice as higher in PD patients compared to controls. EN-RAGE showed a strong positive correlation with serum high-sensitivity CRP (p=0.007) and IL-6 (p=0.002), whereas sRAGE was negatively associated with those inflammatory markers (p=0.001, p=0.031). Even after adjustments for traditional cardiovascular risk factors, both sRAGE and EN-RAGE were independently associated with cIMT (β=-0.230, p=0.037, β=0.155, p=0.045) and VCS (β=-0.205, p=0.049, β=0.197, p=0.156). Multivariate logistic analysis revealed that old age (OR 1.14, 95% CI 1.03-1.25, p=0.009), presence of diabetes (OR 13.4, 95% CI: 1.20-150.18, p=0.035) and elevated plasma EN-RAGE (OR 2.26, 95% CI: 1.05-5.11, p=0.048) were significant predictors for the occurrence of carotid atherosclerosis (cIMT>1.0mm and/or plaque formation). CONCLUSIONS: Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Aorta, Abdominal/diagnostic imaging | - |
dc.subject.MESH | Aortic Diseases/diagnostic imaging | - |
dc.subject.MESH | Aortic Diseases/immunology | - |
dc.subject.MESH | Aortography | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Carotid Artery Diseases/blood | - |
dc.subject.MESH | Carotid Artery Diseases/diagnostic imaging | - |
dc.subject.MESH | Carotid Artery Diseases/immunology* | - |
dc.subject.MESH | Carotid Intima-Media Thickness | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation Mediators/blood* | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Kidney Failure, Chronic/immunology | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy* | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Peritoneal Dialysis/adverse effects* | - |
dc.subject.MESH | Receptor for Advanced Glycation End Products | - |
dc.subject.MESH | Receptors, Immunologic/blood* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | S100 Proteins/blood* | - |
dc.subject.MESH | S100A12 Protein | - |
dc.subject.MESH | Vascular Calcification/diagnostic imaging | - |
dc.subject.MESH | Vascular Calcification/immunology | - |
dc.title | Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jwa-Kyung Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Young Rim Song | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Sung Gyun Kim | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Hyung Jik Kim | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.identifier.doi | 21906738 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 21906738 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915011007362 | - |
dc.subject.keyword | Soluble receptor for advanced glycation end products (sRAGE) | - |
dc.subject.keyword | EN-RAGE | - |
dc.subject.keyword | Peritoneal dialysis | - |
dc.subject.keyword | Carotid intima-media thickness (cIMT) | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.citation.volume | 220 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 208 | - |
dc.citation.endPage | 214 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.220(1) : 208-214, 2012 | - |
dc.identifier.rimsid | 31840 | - |
dc.type.rims | ART | - |
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