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Clinical and ultrasonographic findings affecting nondiagnostic results upon the second fine needle aspiration for thyroid nodules

Authors
 Choi, Yoon Seong  ;  Hong, Soon Won  ;  Kwak, Jin Young  ;  Moon, Hee Jung  ;  Kim, Eun-Kyung 
Citation
 Annals of Surgical Oncology, Vol.19(7) : 2304-2309, 2012 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2012
Abstract
BACKGROUND: The purpose of this study was to investigate the clinical and ultrasonographic (US) findings affecting the nondiagnostic cytology and malignancy rate in thyroid nodules with nondiagnostic cytology upon a second ultrasound-guided fine needle aspiration (US-FNA). MATERIALS AND METHODS: A total of 1124 nodules in 1081 patients (M:F=111:970; mean age, 48.5 years) with 2 or more US-FNAs were included. Clinical and US features were compared between the nodules with nondiagnostic results and diagnostic results from their second FNA using univariate and multivariate analyses. The malignancy rate was analyzed in terms of nondiagnostic cytology. RESULTS: Among 458 nondiagnostic results of the initial FNA, 94 nodules (20.5%) still had nondiagnostic results on the second FNA. Having cystic portion>50% (odds ratio [OR]=2.845, P=.0001), nondiagnostic cytology of the first FNA (OR=2.813, P<.0001), a nodule size≤5 mm (OR=1.742, P=.0331), or hypoechogenicity (OR=1.512, P=.0404) were factors significantly affecting the incidence of nondiagnostic results in the second US-FNA based on multivariate analysis. The malignancy rate was 11.4% in the nodules with nondiagnostic results in the first FNA and 3.2% in the nodules with serial nondiagnostic results in both the first and second FNAs. CONCLUSIONS: The high probability of nondiagnostic results from a second FNA should be considered if a nodule shows cystic portion greater than 50%, nondiagnostic cytology on the first FNA, a nodule size≤5 mm, or hypoechogenicity. The malignancy rate of thyroid nodules with 2 consecutive nondiagnostic results was 3.2%.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-012-2288-4
DOI
10.1245/s10434-012-2288-4
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
최윤성(Choi, Yoon Seong)
홍순원(Hong, Soon Won) ORCID logo https://orcid.org/0000-0002-0324-2414
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89556
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