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The First Korean Case of Candidemia due to Candida dubliniensis

 Nae Yu  ;  Hye Ryoun Kim  ;  Mi-Kyung Lee 
 Annals of Laboratory Medicine, Vol.32(3) : 225-228, 2012 
Journal Title
 Annals of Laboratory Medicine 
Issue Date
Amphotericin B/pharmacology ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida/drug effects ; Candida/isolation & purification* ; Candidemia/diagnosis* ; Candidemia/drug therapy ; Catheterization, Central Venous ; Female ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Flucytosine/pharmacology ; Humans ; Microbial Sensitivity Tests ; Middle Aged ; Pyrimidines/pharmacology ; Triazoles/pharmacology ; Voriconazole
Candida dubliniensis ; Candidemia ; Latex agglutination ; Multiplex PCR
Candidemia due to uncommon Candida spp. appears to be increasing in incidence. C. dubliniensis has been increasingly recovered from individuals not infected with HIV. Identification of C. dubliniensis can be problematic in routine clinical practice due to its phenotypic resemblance to C. albicans. We report the first case of C. dubliniensis candidemia in Korea, which occurred in a 64-yr-old woman who presented with partial seizure, drowsiness, and recurrent fever. Germ-tube positive yeast that was isolated from blood and central venous catheter tip cultures formed smooth, white colonies on sheep blood agar and Sabouraud agar plates, indicative of Candida spp. C. dubliniensis was identified using the Vitek 2 system (bioMerieux, USA), latex agglutination, chromogenic agar, and multiplex PCR. The blood isolate was susceptible to flucytosine, fluconazole, voriconazole, and amphotericin B. After removal of the central venous catheter and initiation of fluconazole treatment, the patient’s condition gradually improved, and she was cleared for discharge from our hospital. Both clinicians and microbiologists should be aware of predisposing factors to C. dubliniensis candidemia in order to promote early diagnosis and appropriate treatment.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yu, Nae(유내)
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