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Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women

DC Field Value Language
dc.contributor.author이경은-
dc.contributor.author이병석-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.contributor.author김혜연-
dc.contributor.author서석교-
dc.contributor.author양효인-
dc.date.accessioned2014-12-19T16:23:39Z-
dc.date.available2014-12-19T16:23:39Z-
dc.date.issued2012-
dc.identifier.issn1046-7408-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89442-
dc.description.abstractPROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCyclooxygenase 2/genetics*-
dc.subject.MESHEndometriosis/ethnology-
dc.subject.MESHEndometriosis/genetics*-
dc.subject.MESHEndometriosis/pathology-
dc.subject.MESHEndometrium/metabolism*-
dc.subject.MESHEndometrium/pathology-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHRisk-
dc.subject.MESHSeverity of Illness Index-
dc.titleCyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorHye Yeon Kim-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorHyo In Yang-
dc.contributor.googleauthorKyung Eun Lee-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi22587873-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02650-
dc.contributor.localIdA02795-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.contributor.localIdA01174-
dc.contributor.localIdA01888-
dc.contributor.localIdA02329-
dc.relation.journalcodeJ00111-
dc.identifier.eissn1600-0897-
dc.identifier.pmid22587873-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2012.01151.x/abstract-
dc.subject.keywordCyclooxygenase-2 gene-
dc.subject.keywordendometriosis-
dc.subject.keywordpolymorphism-
dc.contributor.alternativeNameLee, Kyung Eun-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.alternativeNameChoi, Young Sik-
dc.contributor.alternativeNameKim, Hye Yeon-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameYang, Hyo In-
dc.contributor.affiliatedAuthorLee, Kyung Eun-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.contributor.affiliatedAuthorChoi, Young Sik-
dc.contributor.affiliatedAuthorKim, Hye Yeon-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorYang, Hyo In-
dc.citation.volume68-
dc.citation.number3-
dc.citation.startPage238-
dc.citation.endPage243-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.68(3) : 238-243, 2012-
dc.identifier.rimsid31770-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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