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Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women
DC Field | Value | Language |
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dc.contributor.author | 이경은 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.contributor.author | 김혜연 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 양효인 | - |
dc.date.accessioned | 2014-12-19T16:23:39Z | - |
dc.date.available | 2014-12-19T16:23:39Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1046-7408 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89442 | - |
dc.description.abstract | PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asian Continental Ancestry Group* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cyclooxygenase 2/genetics* | - |
dc.subject.MESH | Endometriosis/ethnology | - |
dc.subject.MESH | Endometriosis/genetics* | - |
dc.subject.MESH | Endometriosis/pathology | - |
dc.subject.MESH | Endometrium/metabolism* | - |
dc.subject.MESH | Endometrium/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Restriction Fragment Length | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Hyo In Yang | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 22587873 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02650 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02329 | - |
dc.relation.journalcode | J00111 | - |
dc.identifier.eissn | 1600-0897 | - |
dc.identifier.pmid | 22587873 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2012.01151.x/abstract | - |
dc.subject.keyword | Cyclooxygenase-2 gene | - |
dc.subject.keyword | endometriosis | - |
dc.subject.keyword | polymorphism | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Eun | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yang, Hyo In | - |
dc.citation.volume | 68 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 238 | - |
dc.citation.endPage | 243 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.68(3) : 238-243, 2012 | - |
dc.identifier.rimsid | 31770 | - |
dc.type.rims | ART | - |
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