Cited 31 times in
High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration: the multiethnic study of atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | 최의영 | - |
dc.date.accessioned | 2014-12-19T16:22:30Z | - |
dc.date.available | 2014-12-19T16:22:30Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89407 | - |
dc.description.abstract | BACKGROUND: Systemic inflammation has been linked to the development of heart failure in population studies including Multi-Ethnic Study of Atherosclerosis (MESA), but little evidence exists regarding potential mechanism of this relationship. In this study, we used longitudinal magnetic resonance imaging follow-up analysis to examine whether C-reactive protein (CRP) levels relate to progressive myocardial functional deterioration as a potential mechanism of incident heart failure. METHODS: Regional myocardial functional data from MESA participants who had baseline CRP measurement and also underwent tagged cardiac magnetic resonance imaging both at baseline and at 5-year follow-up were analyzed. Left ventricular midwall and midslice peak circumferential strain (Ecc), of which a more negative value denotes stronger regional myocardial function, was measured. Circumferential strain change was calculated as the difference between baseline and follow-up Ecc. RESULTS: During the follow-up period, participants (n = 785) with elevated CRP experienced a decrease in strain, independent of age, gender, and ethnicity (B = 0.081, ∆Ecc change per 1 mg/L CRP change, 95% CI 0.036-0.126, P < .001, model 1) and, additionally, beyond systolic blood pressure, heart rate, diabetes, smoking status, body mass index, current medication, and glomerular filtration rate (B = 0.099, 0.052-0.145, P < .001, model 2). The relationship remained statistically significant after further adjustment for left ventricular mass, coronary calcium score, and interim clinical coronary events (B = 0.098, 0.049-0.147, P < .001, model 3). CONCLUSION: Higher CRP levels are related to progressive myocardial functional deterioration independent of subclinical atherosclerosis and clinical coronary events in asymptomatic individuals without previous history of heart disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Atherosclerosis/ethnology | - |
dc.subject.MESH | Atherosclerosis/physiopathology | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/analysis* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart/physiopathology | - |
dc.subject.MESH | Heart Failure/blood | - |
dc.subject.MESH | Heart Failure/diagnosis | - |
dc.subject.MESH | Heart Failure/physiopathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardium | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration: the multiethnic study of atherosclerosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eui-Young Choi | - |
dc.contributor.googleauthor | Raymond T. Yan | - |
dc.contributor.googleauthor | Veronica R.S. Fernandes | - |
dc.contributor.googleauthor | Anders Opdahl | - |
dc.contributor.googleauthor | Antoinette S. Gomes | - |
dc.contributor.googleauthor | Andre L.C. Almeida | - |
dc.contributor.googleauthor | Colin O. Wu | - |
dc.contributor.googleauthor | Kiang Liu | - |
dc.contributor.googleauthor | Jeffrey J. Carr | - |
dc.contributor.googleauthor | Robyn L. McClelland | - |
dc.contributor.googleauthor | David A. Bluemke | - |
dc.contributor.googleauthor | Joao A.C. Lim | - |
dc.identifier.doi | 10.1016/j.ahj.2012.05.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04165 | - |
dc.relation.journalcode | J00069 | - |
dc.identifier.eissn | 1097-6744 | - |
dc.identifier.pmid | 22877812 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0002870312003663 | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Atherosclerosis/ethnology | - |
dc.subject.keyword | Atherosclerosis/physiopathology | - |
dc.subject.keyword | Biomarkers/blood | - |
dc.subject.keyword | C-Reactive Protein/analysis* | - |
dc.subject.keyword | Disease Progression | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Heart/physiopathology | - |
dc.subject.keyword | Heart Failure/blood | - |
dc.subject.keyword | Heart Failure/diagnosis | - |
dc.subject.keyword | Heart Failure/physiopathology* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Magnetic Resonance Imaging | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Myocardium | - |
dc.subject.keyword | Predictive Value of Tests | - |
dc.subject.keyword | Prospective Studies | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.citation.volume | 164 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 258 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, Vol.164(2) : 251-258, 2012 | - |
dc.identifier.rimsid | 34617 | - |
dc.type.rims | ART | - |
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