2 203

Cited 46 times in

Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma

Authors
 D. Y. Kim  ;  H. J. Ryu  ;  J. Y. Choi  ;  J. Y. Park  ;  D. Y. Lee  ;  B. K. Kim  ;  S. U. Kim  ;  S. H. Ahn  ;  C. Y. Chon  ;  K.-H. Han 
Citation
 Alimentary Pharmacology and Therapeutics, Vol.35(11) : 1343-1350, 2012 
Journal Title
 Alimentary Pharmacology and Therapeutics 
ISSN
 0269-2813 
Issue Date
2012
Abstract
BACKGROUND: It remains unclear whether initial compact lipiodol uptake after transarterial chemoembolisation (TACE) is associated with improved survival in patients with hepatocellular carcinoma (HCC). AIM: To reveal the clinical relevance of compact lipiodolisation after TACE. METHODS: We studied 490 patients with unresectable HCC who had first been treated with TACE. Compact lipiodolisation was defined as the absence of an arterial enhancing lesion, reflecting complete lipiodol uptake, as assessed by dynamic computed tomography (CT) 1 month after treatment. The rate of initial compact lipiodolisation was analysed according to multiplicity and size of tumour, and survival of patients who achieved compact lipiodolisation was compared to that of patients who did not. RESULTS: Of the 490 patients, 409 (83.5%) were in Child-Pugh class A and 81 (16.5%) in class B. The rate of initial compact lipiodolisation in single HCCs was higher than that in multinodular HCCs (33.7% vs. 14.6%, P < 0.001). Among single HCCs, the rate of compact lipiodolisation in tumours ≤5, 5-10 and >10 cm was 46.6%, 13.6%, and 0% respectively. The 1-, 3- and 5-year survival rates of patients with compact uptake were 92.7%, 70.7% and 52.4% compared to 60.8%, 28.0% and 16.9% in patients with noncompact lipiodolisation. Multivariate analysis revealed that Child-Pugh class, alpha-fetoprotein level, tumour node metastasis stage, portal vein thrombosis and initial compact lipiodolisation were independent predictors of survival. CONCLUSIONS: Initial compact lipiodol uptake after transarterial chemoembolisation is associated with improved survival in patients with unresectable hepatocellular carcinoma. Accordingly, initial complete lipiodolisation should be considered a relevant therapeutic target.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2012.05089.x/abstract
DOI
10.1111/j.1365-2036.2012.05089.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김도영(Kim, Do Young)
김범경(Kim, Beom Kyung) ORCID logo https://orcid.org/0000-0002-5363-2496
김승업(Kim, Seung Up) ORCID logo https://orcid.org/0000-0002-9658-8050
류한작(Ryu, Han Jak)
박준용(Park, Jun Yong) ORCID logo https://orcid.org/0000-0001-6324-2224
안상훈(Ahn, Sang Hoon) ORCID logo https://orcid.org/0000-0002-3629-4624
이도연(Lee, Do Yun)
전재윤(Chon, Chae Yoon)
최진영(Choi, Jin Young) ORCID logo https://orcid.org/0000-0002-9025-6274
한광협(Han, Kwang-Hyub) ORCID logo https://orcid.org/0000-0003-3960-6539
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89395
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse