Cited 83 times in
Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2014-12-19T16:22:01Z | - |
dc.date.available | 2014-12-19T16:22:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0161-9152 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89392 | - |
dc.description.abstract | Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese women (n = 208, 44.5 ± 0.70 years, 22.4 ± 0.17 kg/m(2)) were categorized into four age groups (22-31, 32-41, 42-51, and 52-63 years; cross-sectional study). Cytokine levels in serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating levels of IL-6 and oxidized low-density lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α), and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6 (P = 0.024), and TNF-α (P = 0.011) and IL-1β (P < 0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F(2)α. Multiple stepwise regression models identified the following factors for contributing to serum IL-6 levels: serum IL-1β, menopause status, WHR, and serum TNF-α in mode I (R(2) = 0.302); serum IL-1β, age, serum TNF-α, and WHR (β = 0.197; P = 0.006) in model II (R(2) = 0.283). Sub-analysis was performed according to menopausal status. Serum IL-6 levels were positively associated with levels of IL-6, TNF-α, and IL-1β in PBMC supernatants (unstimulated) from postmenopausal women, whereas these were negatively associated in premenopausal women. In conclusion, circulating IL-6 levels may be interactively influenced by age and menopause. Additionally, estrogen deprivation after menopause may enhance PBMC cytokine production in postmenopausal women, resulting in increased IL-6 levels which are closely related to oxidative stress. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | AGE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aging/blood* | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Leukocytes, Mononuclear/metabolism* | - |
dc.subject.MESH | Menopause/blood* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress/physiology* | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Women's Health* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Hee Sun Seo | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jean-Marc Cavaillon | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1007/s11357-011-9244-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00052 | - |
dc.identifier.eissn | 1574-4647 | - |
dc.identifier.pmid | 21487705 | - |
dc.subject.keyword | Serum interleukin-6 | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Peripheral mononuclear cells | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Menopause | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 415 | - |
dc.citation.endPage | 425 | - |
dc.identifier.bibliographicCitation | AGE, Vol.34(2) : 415-425, 2012 | - |
dc.identifier.rimsid | 34608 | - |
dc.type.rims | ART | - |
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