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A pharmacodynamic analysis of factors affecting recovery from anesthesia with propofol-remifentanil target controlled infusion
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 이정림 | - |
dc.contributor.author | 한동우 | - |
dc.date.accessioned | 2014-12-19T16:21:43Z | - |
dc.date.available | 2014-12-19T16:21:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1671-4083 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89383 | - |
dc.description.abstract | AIM: To examine individual patient's demographic parameters and clinical variables related to return of consciousness (ROC) and the pharmacodynamic relationship between propofol effect-site concentration (C(e)) and ROC from propofol-remifentanil anesthesia. METHODS: Ninety-four patients received propofol-remifentanil anesthesia using the effect-site target-controlled infusion (TCI) system. All clinical events were noted, and variables possibly related to propofol C(e) at ROC were examined using linear correlation analyses. Pharmacodynamic modeling incorporating covariates was performed using NONMEM (Nonlinear Mixed Effects Modeling) VII software. RESULTS: The C(e) values of propofol at loss of consciousness (LOC) and ROC were 4.4±1.1 μg/mL and 1.1±0.3 μg/mL, respectively. Age was negatively correlated with propofol C(e) at ROC (r=-0.48, P<0.01). Including age as a covariate in C(e50) (the effect-site concentration associated with 50% probability of return of consciousness) and λ (the steepness of the concentration-versus-response relationship) significantly improved the performance of the basic model based on the likelihood ratio test, with a significant decrease in the minimum value of the objective function. The C(e50) in 25-, 50-, and 75-year-old patients was predicted to be 1.38, 1.06, and 0.74 μg/mL, respectively. The λ in 25-, 50-, and 75-year-old patients was predicted to be 12.23, 8.70, and 5.18, respectively. CONCLUSION: Age significantly affects the relationship between propofol C(e) and ROC, and pharmacodynamic modeling including age could lead to better predictions of ROC during emergence from propofol-remifentanil anesthesia. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA PHARMACOLOGICA SINICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anesthesia | - |
dc.subject.MESH | Anesthesia Recovery Period* | - |
dc.subject.MESH | Anesthetics, Intravenous | - |
dc.subject.MESH | Drug Delivery Systems/trends* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infusions, Intravenous | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Piperidines/administration & dosage* | - |
dc.subject.MESH | Piperidines/pharmacology | - |
dc.subject.MESH | Propofol/administration & dosage* | - |
dc.subject.MESH | Propofol/pharmacology | - |
dc.title | A pharmacodynamic analysis of factors affecting recovery from anesthesia with propofol-remifentanil target controlled infusion | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Bon-nyeo Koo | - |
dc.contributor.googleauthor | Jeong-rim Lee | - |
dc.contributor.googleauthor | Gyu-jeong Noh | - |
dc.contributor.googleauthor | Jae-hoon Lee | - |
dc.contributor.googleauthor | Young-ran Kang | - |
dc.contributor.googleauthor | Dong-woo Han | - |
dc.identifier.doi | 22842732 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A03098 | - |
dc.contributor.localId | A04274 | - |
dc.contributor.localId | A03092 | - |
dc.relation.journalcode | J00030 | - |
dc.identifier.eissn | 1745-7254 | - |
dc.identifier.pmid | 22842732 | - |
dc.identifier.url | http://dx.doi.org/10.1038/aps.2012.85 | - |
dc.subject.keyword | anesthesia | - |
dc.subject.keyword | effect-site concentration | - |
dc.subject.keyword | propofol | - |
dc.subject.keyword | pharmacodynamic modeling | - |
dc.subject.keyword | return of consciousness | - |
dc.subject.keyword | target-controlled infusion | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Lee, Jeong Rim | - |
dc.contributor.alternativeName | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Rim | - |
dc.contributor.affiliatedAuthor | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.citation.volume | 33 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1080 | - |
dc.citation.endPage | 1084 | - |
dc.identifier.bibliographicCitation | ACTA PHARMACOLOGICA SINICA, Vol.33(8) : 1080-1084, 2012 | - |
dc.identifier.rimsid | 34602 | - |
dc.type.rims | ART | - |
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