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Smooth emergence in men undergoing nasal surgery: the effect site concentration of remifentanil for preventing cough after sevoflurane-balanced anaesthesia
DC Field | Value | Language |
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dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 이정림 | - |
dc.contributor.author | 최승호 | - |
dc.date.accessioned | 2014-12-19T16:20:37Z | - |
dc.date.available | 2014-12-19T16:20:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0001-5172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89350 | - |
dc.description.abstract | BACKGROUND: Suppression of cough during emergence after nasal surgery is practical to avoid bleeding from the surgical site. Previously recommended effect-site concentration of remifentanil for preventing cough during emergence is restricted to female patients undergoing thyroid surgery, so we evaluated effective effect-site concentration of remifentanil for preventing cough during emergence for men undergoing nasal surgery. METHODS: Twenty-four American Society of Anesthesiologists (ASA) physical status I or II, between the ages of 18 and 60 years old, non-smoker male patients undergoing nasal surgery were enrolled in this study. The effective effect-site concentration for 50% of patients (EC(50) ) and and that for 95% of patients (EC(95) ) of remifentanil for preventing cough were determined by Dixon's up-and-down method and by isotonic regression method with a bootstrapping approach. Haemodynamic variables were compared in patients with cough and without cough during emergence. RESULTS: The EC(50) of remifentanil for preventing cough during emergence by Dixon's method was 2.17 ng/ml [standard deviation (SD) 0.38]. The estimated EC(50) and EC(95) of remifentanil using isotonic regression model with a bootstrapping approach were 2.35 ng/ml [95% confidence interval (CI) 1.89-2.66] and 2.94 ng/ml (95% CI 2.83-2.97), respectively. Mean arterial pressure and heart rate were significantly higher in patients with cough during emergence. Three out of 13 patients that received more than 2.5 ng/ml of remifentanil experienced a brief episode of bradypnea. CONCLUSIONS: The EC(95) of remifentanil for preventing cough in men after nasal surgery is 2.94 ng/ml. Remifentanil target-controlled infusion with established effect-site concentration could suppress cough in men during emergence from sevoflurane anaesthesia after nasal surgery, though reversible respiratory depression might arise at high effect-site concentration of remifentanil. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA ANAESTHESIOLOGICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anesthesia, Inhalation | - |
dc.subject.MESH | Anesthetics, Inhalation/adverse effects* | - |
dc.subject.MESH | Blood Pressure/drug effects | - |
dc.subject.MESH | Cough/prevention & control* | - |
dc.subject.MESH | Heart Rate/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methyl Ethers/adverse effects* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nose/surgery* | - |
dc.subject.MESH | Piperidines/therapeutic use* | - |
dc.title | Smooth emergence in men undergoing nasal surgery: the effect site concentration of remifentanil for preventing cough after sevoflurane-balanced anaesthesia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | E. M. CHOI | - |
dc.contributor.googleauthor | W-K. PARK | - |
dc.contributor.googleauthor | S-H. CHOI | - |
dc.contributor.googleauthor | S. SOH | - |
dc.contributor.googleauthor | J-R. LEE | - |
dc.identifier.doi | 22220983 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A03098 | - |
dc.contributor.localId | A04101 | - |
dc.contributor.localId | A01960 | - |
dc.relation.journalcode | J00006 | - |
dc.identifier.eissn | 1399-6576 | - |
dc.identifier.pmid | 22220983 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2011.02620.x/abstract | - |
dc.subject.keyword | Adolescent | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Anesthesia, Inhalation | - |
dc.subject.keyword | Anesthetics, Inhalation/adverse effects* | - |
dc.subject.keyword | Blood Pressure/drug effects | - |
dc.subject.keyword | Cough/prevention & control* | - |
dc.subject.keyword | Heart Rate/drug effects | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Methyl Ethers/adverse effects* | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Nose/surgery* | - |
dc.subject.keyword | Piperidines/therapeutic use* | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Lee, Jeong Rim | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Rim | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 498 | - |
dc.citation.endPage | 503 | - |
dc.identifier.bibliographicCitation | ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.56(4) : 498-503, 2012 | - |
dc.identifier.rimsid | 34550 | - |
dc.type.rims | ART | - |
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