Cited 33 times in
Clinical Benefit of Liver Stiffness Measurement at 3 Months after Kasai Hepatoportoenterostomy to Predict the Liver Related Events in Biliary Atresia
DC Field | Value | Language |
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dc.contributor.author | 고홍 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 박국인 | - |
dc.contributor.author | 한석주 | - |
dc.contributor.author | 한승민 | - |
dc.date.accessioned | 2014-12-18T09:59:34Z | - |
dc.date.available | 2014-12-18T09:59:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89214 | - |
dc.description.abstract | BACKGROUND: The progression of hepatic fibrosis may result in decompensated hepatic failure with cirrhosis, liver related events (LRE) such as ascites, variceal bleeding, and death after successful and timely Kasai hepatoportoenterostomy (HPE) in biliary atresia. The aim of this study is to suggest clinical benefit of the liver stiffness measurement (LSM) using transient elastography at 3 months after the Kasai operation to predict LRE. METHODS: Between January 2007 and December 2011, 69 eligible biliary atresia patients who underwent Kasai HPE and performed transient elastography before and 3 months after HPE were included. The occurrences of LRE were analyzed for all patients. All patients were divided into 2 groups (with and without LRE) for comparison. Multivariate analysis was used to detect the independent risk factors of LRE. The area under the receiver operation characteristics curve (AUROC) was used to establish the LSM optimal cutoff value of 3 months after Kasai operation in predicting LRE. RESULTS: LSM value, aminotransferase, albumin, bilirubin, and PT-INR significantly differed among the two groups. Multivariate analysis demonstrated LSM value as the most powerful independent factor of the development of LRE. The cut-off value of 19.9 kPa was calculated to be optimal for predicting LRE development with total sensitivity and specificity of 1.804. AUROC resulted in 0.943, with sensitivity of 85.3% and specificity of 95.2%. CONCLUSIONS: The LSM value of 3 months after Kasai HPE can be a useful predictor of LRE development. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biliary Atresia/diagnosis* | - |
dc.subject.MESH | Biliary Atresia/etiology* | - |
dc.subject.MESH | Biliary Atresia/surgery | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Elasticity Imaging Techniques*/methods | - |
dc.subject.MESH | Elasticity Imaging Techniques*/standards | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Liver/diagnostic imaging* | - |
dc.subject.MESH | Liver/pathology* | - |
dc.subject.MESH | Liver/surgery | - |
dc.subject.MESH | Liver Function Tests | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Clinical Benefit of Liver Stiffness Measurement at 3 Months after Kasai Hepatoportoenterostomy to Predict the Liver Related Events in Biliary Atresia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.contributor.googleauthor | Kook In Park | - |
dc.contributor.googleauthor | Seok Joo Han | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.identifier.doi | 10.1371/journal.pone.0080652 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00156 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A01438 | - |
dc.contributor.localId | A04288 | - |
dc.contributor.localId | A04299 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24260445 | - |
dc.subject.keyword | Biliary Atresia/diagnosis* | - |
dc.subject.keyword | Biliary Atresia/etiology* | - |
dc.subject.keyword | Biliary Atresia/surgery | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Child, Preschool | - |
dc.subject.keyword | Elasticity Imaging Techniques*/methods | - |
dc.subject.keyword | Elasticity Imaging Techniques*/standards | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Follow-Up Studies | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Infant | - |
dc.subject.keyword | Infant, Newborn | - |
dc.subject.keyword | Liver/diagnostic imaging* | - |
dc.subject.keyword | Liver/pathology* | - |
dc.subject.keyword | Liver/surgery | - |
dc.subject.keyword | Liver Function Tests | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | ROC Curve | - |
dc.subject.keyword | Reference Values | - |
dc.subject.keyword | Reproducibility of Results | - |
dc.subject.keyword | Risk Factors | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.alternativeName | Kim, Seung | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.alternativeName | Han, Seok Joo | - |
dc.contributor.alternativeName | Hahn, Seung Min | - |
dc.contributor.affiliatedAuthor | Koh, Hong | - |
dc.contributor.affiliatedAuthor | Kim, Seung | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Han, Seok Joo | - |
dc.contributor.affiliatedAuthor | Hahn, Seung Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e80652 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(11) : e80652, 2013 | - |
dc.identifier.rimsid | 34454 | - |
dc.type.rims | ART | - |
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