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Anticancer Effect of Phellinus linteus; Potential Clinical Application in Treating Pancreatic Ductal Adenocarcinoma

Authors
 Chang Moo Kang  ;  Dai Hoon Han  ;  Ho Kyoung Hwnag  ;  Sung Hoon Choi  ;  Woo Jung Lee 
Citation
 Journal of Carcinogenesis & Mutagenesis, Vol.S9(001) : 1-8, 2013 
Journal Title
 Journal of Carcinogenesis & Mutagenesis 
ISSN
 2157-2518 
Issue Date
2013
Keywords
Pancreatic cancer ; Phellinus linteus ; Basidiomycete ; Adjuvant chemotherapy
Abstract
Pancreatic cancer (ductal adenocarcinoma) is one of the most lethal malignancies in gastrointestinal system. Till now, only margin-negative pancreatectomy is known to be the best treatment option for long-term survival. However, the resection rate is reported to be less than 20%. Even in cases of curative resection, most patients generally experience disease recurrence and ultimately die of metastatic disease. Therefore, surgery alone is not enough and adjuvant systemic chemotherapy should be considered for proper management of pancreatic cancer. But, its related toxicity and insufficient oncologic effect requires development of less toxic and more effective alternative treatments for pancreatic cancer. Phellinus linteus (PL), a basidiomycete, is a species of mushroom, which is reported to have the most potent antitumor effect of the basidiomycetes. Recently, there are accumulating researches discovering biologic mechanisms of PL in antitumor effect. However, very few studies were done in pancreatic cancer treatment. In this review, literatures demonstrating the anticancer effects of PL were summarized and some encouraging research data suggesting mushroom component can be alternative approach even in treating pancreatic cancer were reviewed, including our preliminary data suggesting the potential clinical application of PL in treating pancreatic cancer.
Files in This Item:
T201305695.pdf Download
DOI
10.4172/2157-2518.S9-001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Choi, Sung Hoon(최성훈)
Han, Dai Hoon(한대훈) ORCID logo https://orcid.org/0000-0003-2787-7876
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89190
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